Acyclovir / Hydrocortisone Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 4, 2025.

Applies to acyclovir/hydrocortisone topical: topical application cream.

Serious side effects

Along with its needed effects, acyclovir/hydrocortisone topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acyclovir / hydrocortisone topical:

Rare side effects

• burning, itching, redness, rash, swelling, soreness, or tingling at the application site
• change in skin color at the application site
• dryness or flaking of the skin
• flushing or redness of the skin
• unusually warm skin

Incidence not known

• blistering, burning, or crusting of the skin
• itching, scaling, severe redness, soreness, or swelling of the skin

For healthcare professionals

Applies to acyclovir / hydrocortisone topical: topical cream.

General adverse events

The most frequently reported side effects were local skin reactions and included drying or flaking of the skin; burning or tingling; erythema; pigmentation changes; and application site reactions including signs/symptoms of inflammation.^[Ref]

Local

• Frequency not reported: Dry skin, flaking skin, burning, tingling, erythema, pigmentation changed, inflammation^[Ref]

Hypersensitivity

• Frequency not reported: Contact allergy, sensitization^[Ref]

Dermatologic

• Frequency not reported: Contact dermatitis^[Ref]

Further information

Acyclovir/hydrocortisone topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer