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Xerese Cream

Generic Name: acyclovir and hydrocortisone topical (a SYE kloe vir and HYE droe KOR ti sone TOP ik al)
Brand Names: Xerese

What is Xerese?

Xerese cream contains a combination of acyclovir and hydrocortisone. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Hydrocortisone is a topical (for the skin) corticosteroid. It reduces the actions of chemicals in the body that cause inflammation.

Xerese cream is a prescription medicine used to treat cold sores in people who are at least 12 years old.

Xerese will not cure or prevent cold sores caused by herpes, but it can lessen the symptoms of the infection.

Important information

Xerese will not cure or prevent herpes, but it can lessen the symptoms of the infection.

Herpes infections are contagious and you can infect other people, even while you are being treated with Xerese. Acyclovir and hydrocortisone will not prevent the spread of genital herpes. Avoid sexual intercourse or use a latex condom to prevent spreading the virus to others.

Xerese is for use for cold sores on the lips and around the mouth. This medication will not treat herpes lesions that affect the genitals or the eyes.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Stop using Xerese and call your doctor at once if you have severe burning, stinging, or irritation of treated skin.

Before taking this medicine

You should not Xerese if you are allergic to acyclovir (Zovirax) or hydrocortisone.

To make sure you can safely use Xerese, tell your doctor if you have a weak immune system (caused by disease by or using certain medicines).

FDA pregnancy category B. Xerese cream is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether acyclovir and hydrocortisone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Xerese should not be used on a child younger than 12 years old.

Do not share Xerese cream with other people, even if they have the same symptoms you have.

How should I use Xerese?

Use Xerese cream exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Xerese cream is for use for cold sores on the lips and around the mouth. This medication will not treat herpes lesions that affect the genitals or the eyes.

Treatment with Xerese should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Wash your hands before and after applying the medicine. Also wash the skin area to be treated.

Apply a thin layer of Xerese cream to cover the cold sore or tingly area. Do not rub the cold sore, to avoid making it worse or spreading the virus to other areas of your mouth. Do not cover the treated skin with a bandage.

Do not bathe, shower, or swim for at least 30 minutes after applying this medication.

Xerese cream may be applied 5 times daily for 5 days. Follow your doctor's instructions.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Talk with your doctor if your symptoms do not improve after 2 weeks of treatment.

Store at room temperature away from moisture and heat. Do not freeze. Keep the tube tightly closed when not in use.

Xerese dosing information

Usual Adult Dose for Herpes Simplex Labialis:

Apply topically 5 times per day for 5 days.

Comments:
-Therapy should be started as early as possible after onset of signs/symptoms (i.e., during prodromal phase or when lesions appear).

Approved indication: For the early treatment of recurrent herpes labialis to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time

Usual Pediatric Dose for Herpes Simplex Labialis:

6 years or older: Apply topically 5 times per day for 5 days.

Comments:
-Therapy should be started as early as possible after onset of signs/symptoms (i.e., during prodromal phase or when lesions appear).

Approved indication: For the early treatment of recurrent herpes labialis to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of Xerese is unlikely to occur.

What should I avoid while using Xerese?

Avoid getting this medication in your eyes, nose, or mouth. If this does happen, rinse with water. When treating a cold sore, apply the medication only the outer part of your lips.

Do not apply Xerese cream to your genitals.

Do not apply sunscreen, lip balm, or cosmetics to the treated cold sore area.

Herpes infections are contagious and you can infect other people, even while you are being treated with Xerese. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Xerese side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Xerese: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have severe burning, stinging, or irritation of treated skin.

Less serious Xerese side effects may include:

  • mild burning or tingling after applying the medicine;

  • skin dryness or flaking;

  • bitter taste in your mouth after applying the medicine; or

  • skin redness or discoloration;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Xerese?

It is not likely that other drugs you take orally or inject will have an effect on topically applied acyclovir and hydrocortisone. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Xerese.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xerese only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 1.02. Revision Date: 2014-06-05, 2:31:18 PM.

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