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Xerese Side Effects

Generic Name: acyclovir / hydrocortisone topical

Note: This page contains side effects data for the generic drug acyclovir / hydrocortisone topical. It is possible that some of the dosage forms included below may not apply to the brand name Xerese.

For the Consumer

Applies to acyclovir / hydrocortisone topical: topical application cream

As well as its needed effects, acyclovir / hydrocortisone topical may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking acyclovir / hydrocortisone topical, check with your doctor immediately:

  • Burning, itching, redness, rash, swelling, soreness, or tingling at the application site
  • change in skin color at the application site
  • dryness or flaking of the skin
  • flushing or redness of the skin
  • unusually warm skin
Incidence not known:
  • Blistering, burning, or crusting of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to acyclovir / hydrocortisone topical: topical cream


During clinical trials, most side effects were local skin reactions and occurred around the application site.[Ref]


Uncommon (0.1% to 1%): Local skin reactions in application site area (including drying or flaking of skin, burning or tingling after application, erythema, pigmentation changes, application site reaction [including signs/symptoms of inflammation])
Frequency not reported: High and cumulative irritation potential[Ref]

A high and cumulative irritation potential under occlusive and semiocclusive conditions was reported during a 21-day cumulative irritation trial.[Ref]


Frequency not reported: Contact allergy, sensitization to hydrocortisone, possible sensitization to drug's base[Ref]

During a photosafety study, one subject developed a contact allergy to propylene glycol (one of the inactive ingredients of the cream base).[Ref]


Frequency not reported: Contact dermatitis[Ref]


1. "Product Information. Xerese (acyclovir-hydrocortisone topical)." Meda Pharmaceuticals, Somerset, NJ.

It is possible that some side effects of Xerese may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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