Acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine Side Effects
Medically reviewed by Drugs.com. Last updated on Jun 13, 2022.
Applies to acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine: oral capsule, oral powder for reconstitution, oral tablet.
Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).
In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
Acetaminophen is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.
Get emergency medical help if you have any of these signs of an allergic reaction while taking acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Stop using this medicine and call your doctor at once if you have:
fast, slow, or uneven heart rate;
severe dizziness, feeling like you might pass out;
mood changes, confusion, hallucinations, tremor, seizure (convulsions);
little or no urinating;
nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).
Common side effects may include:
mild nausea, diarrhea, upset stomach;
dry mouth, nose, or throat;
feeling nervous, restless, irritable, or anxious; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
More about acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine
- Check interactions
- Reviews (1)
- Drug images
- Dosage information
- Drug class: upper respiratory combinations
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.