Skip to main content

Acetaminophen / caffeine / chlorpheniramine / hydrocodone / phenylephrine Side Effects

Applies to acetaminophen/caffeine/chlorpheniramine/hydrocodone/phenylephrine: oral tablet.


Cardiovascular side effects have included hypertension, postural hypotension, tachycardia, and palpitations.[Ref]


Genitourinary side effects have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.[Ref]

Nervous system

Nervous system side effects have included sedation, drowsiness, mental clouding, lethargy, and impairment of mental and physical performance.[Ref]


Psychiatric side effects have included anxiety, fear, dysphoria, psychic dependence, and mood changes.[Ref]


Ocular side effects have included blurred vision.[Ref]


Gastrointestinal side effects have included nausea and vomiting.[Ref]


Respiratory side effects have included dose-related respiratory depression.[Ref]

More about acetaminophen / caffeine / chlorpheniramine / hydrocodone / phenylephrine

Related treatment guides


1. Product Information. Hycomine Compound (APAP/caffeine/CPM/hydrocodone/PE). Endo Laboratories LLC. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.