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Acetaminophen / caffeine / chlorpheniramine / hydrocodone / phenylephrine Side Effects

Applies to acetaminophen/caffeine/chlorpheniramine/hydrocodone/phenylephrine: oral tablet


Cardiovascular side effects have included hypertension, postural hypotension, tachycardia, and palpitations.[Ref]


Genitourinary side effects have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.[Ref]

Nervous system

Nervous system side effects have included sedation, drowsiness, mental clouding, lethargy, and impairment of mental and physical performance.[Ref]


Psychiatric side effects have included anxiety, fear, dysphoria, psychic dependence, and mood changes.[Ref]


Ocular side effects have included blurred vision.[Ref]


Gastrointestinal side effects have included nausea and vomiting.[Ref]


Respiratory side effects have included dose-related respiratory depression.[Ref]


1. "Product Information. Hycomine Compound (APAP/caffeine/CPM/hydrocodone/PE)." Endo Laboratories LLC, Chadds Ford, PA.

Some side effects of acetaminophen / caffeine / chlorpheniramine / hydrocodone / phenylephrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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