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Acetaminophen / Caffeine / Chlorpheniramine / Hydrocodone / Phenylephrine Side Effects

Applies to acetaminophen/caffeine/chlorpheniramine/hydrocodone/phenylephrine: oral tablet.

Cardiovascular adverse events

Cardiovascular side effects have included hypertension, postural hypotension, tachycardia, and palpitations.[Ref]

Genitourinary

Genitourinary side effects have included ureteral spasm, spasm of vesicle sphincters, and urinary retention.[Ref]

Nervous system

Nervous system side effects have included sedation, drowsiness, mental clouding, lethargy, and impairment of mental and physical performance.[Ref]

Psychiatric

Psychiatric side effects have included anxiety, fear, dysphoria, psychic dependence, and mood changes.[Ref]

Ocular

Ocular side effects have included blurred vision.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting.[Ref]

Respiratory

Respiratory side effects have included dose-related respiratory depression.[Ref]

References

1. (2022) "Product Information. Hycomine Compound (APAP/caffeine/CPM/hydrocodone/PE)." Endo Laboratories LLC

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Further information

Acetaminophen/caffeine/chlorpheniramine/hydrocodone/phenylephrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.