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Acanya Side Effects

Generic name: benzoyl peroxide / clindamycin topical

Medically reviewed by Last updated on Feb 8, 2021.

Note: This document contains side effect information about benzoyl peroxide / clindamycin topical. Some of the dosage forms listed on this page may not apply to the brand name Acanya.

In Summary

Common side effects of Acanya include: xeroderma. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to benzoyl peroxide/clindamycin topical: external gel, external kit

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad irritation where this drug is used.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Irritation where this drug is used.
  • Dry skin.
  • Itching.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit


The most frequently reported side effects were erythema, scaling, peeling, dry skin, and itching.[Ref]


Very common (10% or more): Erythema (up to 28%), scaling (up to 19%), peeling (up to 17%), dry skin (up to 15%), itching (up to 15%)

Common (1% to 10%): Pruritus, sunburn, burning, stinging

Uncommon (0.1% to 1%): Contact dermatitis, rash, acne worsened

Postmarketing reports: Urticaria[Ref]


Frequency not reported: Colitis

Postmarketing reports: Pseudomembranous colitis, hemorrhagic diarrhea, diarrhea, abdominal pain[Ref]


Postmarketing reports: Anaphylaxis, allergic reaction[Ref]


Common (1% to 10%): Application site reaction

Uncommon (0.1% to 1%): Application site pain, application site exfoliation, application site irritation

Postmarketing reports: Discoloration[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Paresthesia[Ref]


1. "Product Information. Duac (benzoyl peroxide-clindamycin topical)." Stiefel Laboratories Inc, Coral Gables, FL.

2. "Product Information. BenzaClin Topical Gel (benzoyl peroxide-clindamycin topical)" Aventis Pharmaceuticals, Swiftwater, PA.

3. "Product Information. Onexton (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals, Costa Mesa, CA.

4. "Product Information. Acanya (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals, Costa Mesa, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.