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Acalabrutinib Side Effects

Medically reviewed by Last updated on Mar 14, 2023.

Applies to acalabrutinib: oral tablet.

Serious side effects of Acalabrutinib

Along with its needed effects, acalabrutinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acalabrutinib:

More common

Other side effects of Acalabrutinib

Some side effects of acalabrutinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to acalabrutinib: oral capsule, oral tablet.


The most common adverse reactions (reported incidence of 20% or greater) were anemia, thrombocytopenia, headache, neutropenia, diarrhea, fatigue, myalgia, and bruising.[Ref]


Very common (10% or more): Bleeding events (50%)

Common (1% to 10%): Hemorrhage/hematoma

Uncommon (0.1% to 1%): Atrial fibrillation, atrial flutter[Ref]


Very common (10% or more): Decreased hemoglobin (46%), decreased platelets (44%), decreased neutrophils (36%), neutropenia (23%), anemia (11%)

Common (1% to 10%): Thrombocytopenia[Ref]

Nervous system

Very common (10% or more): Headache (39%)[Ref]


Very common (10% or more): Diarrhea (31%), nausea (19%), abdominal pain (15%), constipation (15%), vomiting (13%)[Ref]


Very common (10% or more): Bruising/petechiae/ecchymosis/contusion (21%), rash (18%)[Ref]


Very common (10% or more): Myalgia (21%)[Ref]


Very common (10% or more): Second primary malignancies (11%)

Common (1% to 10%): Skin cancer[Ref]


Common (1% to 10%): Increased creatinine[Ref]


Common (1% to 10%): Epistaxis

Frequency not reported: Pneumonia[Ref]


Very common (10% or more): Fatigue (28%)

Frequency not reported: Infections[Ref]

Frequently asked questions


1. Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.