(PRAZ oh sin)
- Prazosin HCl
- Prazosin Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Minipress: 1 mg, 2 mg, 5 mg
Generic: 1 mg, 2 mg, 5 mg
Brand Names: U.S.
- Alpha1 Blocker
Competitively inhibits postsynaptic alpha-adrenergic receptors which results in vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure
Vd: 0.5 L/kg
Extensively hepatic via demethylation and conjugation
Feces; urine (6% to 10% as unchanged drug)
Onset of Action
Antihypertensive: Within 2 hours; Peak effect: 2 to 4 hours
Time to Peak
Plasma: ~3 hours
Duration of Action
10 to 24 hours
2 to 3 hours, prolonged with CHF
Highly bound (97%)
Use: Labeled Indications
Hypertension: Treatment of hypertension
The 2014 guideline for the management of high blood pressure in adults (Eighth Joint National Committee [JNC 8]) does not recommend the use of prazosin in the treatment of hypertension (James 2013).
Off Label Uses
Post-traumatic stress disorder (PTSD) related nightmares and sleep disruption
Data from three double-blind, placebo-controlled trials, supports the use of prazosin in reducing trauma nightmares and improving sleep disruption in both veteran combat related and civilian noncombat related chronic PTSD [Raskind 2003], [Raskind 2007], [Taylor 2008]. Additional trials may be necessary to further define the role of prazosin in this condition.
Based on the American Psychiatric Association practice guidelines for the treatment of acute stress disorder and posttraumatic stress disorder, prazosin appears effective for the management of trauma-related nightmares and sleep disruption associated with PTSD. Similarly, based on the World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the treatment of anxiety, obsessive-compulsive and post-traumatic stress disorder, prazosin may reduce nightmares and be an alternative therapy for treatment-resistant cases.
Data from a limited number of patients in four double-blind, placebo-controlled trials and an open-label dose response trial suggest that prazosin may be beneficial for the treatment of Raynaud phenomenon [Nielson 1983], [Russell 1985], [Surwit 1984], [Wollersheim 1988], [Wollersheim 1986]. Additional data may be necessary to further define the role of prazosin in this condition.
Known sensitivity to quinazolines, prazosin, or any component of the formulation
Hypertension: Oral: Initial: 1 mg/dose 2 or 3 times daily, increased slowly to usual dosage range of 6 to 15 mg/day in divided doses or alternatively, 1 to 5 mg twice daily (ASH/ISH [Weber 2014]). Dose may be increased up to 20 mg/day in divided doses; however, some patients may benefit from up to 40 mg/day in divided doses.
Concomitant diuretics or other antihypertensives: When adding a diuretic or other antihypertensive, decrease prazosin dose to 1 or 2 mg 3 times daily and retitrate.
PTSD-related nightmares and sleep disruption (off-label use): Oral: Initial: 1 mg at bedtime; after 2 to 3 days increase dose to 2 mg at bedtime, then adjust dosage based on response and tolerability in 1 to 2 mg increments every 7 days up to a maximum of 15 mg/day (Raskind 2003; Raskind 2007; Taylor 2008). (Titration as rapid as every 2 to 3 days has been evaluated [Taylor 2008]). Usual dose range: 3 to 15 mg at bedtime (APA [Benedek, 2009]). Civilian patients, especially females may require lower doses (Taylor 2008).
Raynaud phenomenon (off-label use): Oral: Initial: 0.5 to 1 mg once daily (at bedtime) or 0.5 mg twice daily; gradually adjust dose based on response and tolerability up 12 mg/day in 2 to 3 divided doses (Nielson 1983; Russell 1985; Wollersheim 1988)
Refer to adult dosing. In the management of hypertension, consider lower initial doses and titrate to response (Aronow 2011).
Hypertension (off-label use): Oral: Children: Initial: 0.05 to 0.1 mg/kg/day in 3 divided doses; maximum: 0.5 mg/kg/day (not to exceed 20 mg) (NHBPEP, Fourth Report)
Dosing: Renal Impairment
There are no dosage adjustments provided in the manufacturer’s labeling. It has been recommended to initiate at low dosages; titrate cautiously (Aronoff 2007).
Dosing: Hepatic Impairment
There are no dosage adjustments provided in the manufacturer’s labeling.
Store at 20°C to 25°C (68°F to 77°F). Protect from moisture and light.
Alpha-/Beta-Agonists: Alpha1-Blockers may diminish the vasoconstricting effect of Alpha-/Beta-Agonists. Similarly, Alpha-/Beta-Agonists may antagonize Alpha1-Blocker vasodilation. Monitor therapy
Alpha1-Agonists: Alpha1-Blockers may diminish the vasoconstricting effect of Alpha1-Agonists. Similarly, Alpha1-Agonists may antagonize Alpha1-Blocker vasodilation. Monitor therapy
Alpha1-Blockers: May enhance the antihypertensive effect of other Alpha1-Blockers. Avoid combination
Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. If blood pressure lowering therapy cannot be withheld, amifostine should not be administered. Consider therapy modification
Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy
Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). Monitor therapy
Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Beta-Blockers: May enhance the orthostatic hypotensive effect of Alpha1-Blockers. The risk associated with ophthalmic products is probably less than systemic products. Exceptions: Levobunolol; Metipranolol. Monitor therapy
Brigatinib: May diminish the antihypertensive effect of Antihypertensive Agents. Brigatinib may enhance the bradycardic effect of Antihypertensive Agents. Monitor therapy
Brimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Calcium Channel Blockers: Alpha1-Blockers may enhance the hypotensive effect of Calcium Channel Blockers. Monitor therapy
Dapoxetine: May enhance the orthostatic hypotensive effect of Alpha1-Blockers. Monitor therapy
Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. Monitor therapy
Herbs (Hypertensive Properties): May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy
Herbs (Hypotensive Properties): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Monitor therapy
Levodopa: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa. Monitor therapy
Lormetazepam: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy
Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Nitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. Monitor therapy
Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Consider therapy modification
Pentoxifylline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Pholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine. Monitor therapy
Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Alpha1-Blockers. Management: Ensure patient is stable on one agent prior to initiating the other, and always initiate combination using the lowest possible dose of the drug being added. When tadalafil is used for treatment of BPH, concurrent alpha 1-blockers are not recommended. Consider therapy modification
Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Quinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Rilmenidine: Alpha1-Blockers may enhance the hypotensive effect of Rilmenidine. Monitor therapy
Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy
Increased urinary VMA 17%, norepinephrine metabolite 42%; therefore, false positives may occur in screening for pheochromocytoma. If elevated VMA is found, discontinue prazosin and retest after one month.
Cardiovascular: Palpitations (5%)
Central nervous system: Dizziness (10%), drowsiness (8%), headache (8%), decreased energy (7%)
Gastrointestinal: Nausea (5%)
Neuromuscular & skeletal: Weakness (7%)
1% to 4%:
Cardiovascular: Edema, orthostatic hypotension, syncope
Central nervous system: Depression, nervousness, vertigo
Dermatologic: Skin rash
Gastrointestinal: Constipation, diarrhea, vomiting, xerostomia
Genitourinary: Urinary frequency
Ophthalmic: Blurred vision, injected sclera
Respiratory: Dyspnea, epistaxis, nasal congestion
<1% (Limited to important or life-threatening): Abdominal distress, abnormal hepatic function tests, alopecia, angina pectoris, arthralgia, bradycardia, cataplexy, cataract (both development of cataract and disappearance have been reported), diaphoresis, eye pain, fever, flushing, gynecomastia, hallucination, hypersensitivity reaction, impotence, insomnia, leukopenia, lichen planus, malaise, myocardial infarction, narcolepsy (worsened), pain, pancreatitis, paresthesia, positive ANA titer, priapism, pruritus, retinal pigment changes (mottled), retinopathy (serous), systemic lupus erythematosus, tachycardia, tinnitus, urinary incontinence, urticaria, vasculitis
Concerns related to adverse effects:
• Angina: Discontinue if symptoms of angina occur or worsen.
• CNS depression: May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery or driving).
• Floppy iris syndrome: Intraoperative floppy iris syndrome has been observed in cataract surgery patients who were on or were previously treated with alpha1-blockers; modification to surgical technique may be necessary. There appears to be no benefit in discontinuing alpha1-blockers prior to surgery.
• Orthostatic hypotension/syncope: May cause significant orthostatic hypotension and syncope with sudden loss of consciousness, especially within 30 to 90 minutes of the first dose; anticipate a similar effect if therapy is interrupted for a few days, if dosage is rapidly increased, or if another antihypertensive drug (particularly vasodilators or a beta-blocker) or a phosphodiesterase 5 (PDE 5) inhibitor (eg, sildenafil, tadalafil, vardenafil) is introduced. Severe tachycardia (120 to 160 beats/minute) has occasionally been reported prior to a syncopal episode. Patients should be cautioned about alcohol use and performing hazardous tasks when starting new therapy or adjusting dosage upward.
• Priapism: Priapism and prolonged erections have been reported; seek immediate medical assistance for erections lasting longer than 4 hours.
• Heart failure: In a scientific statement from the American Heart Association, prazosin has been determined to be an agent that may exacerbate underlying myocardial dysfunction (magnitude: moderate) (AHA [Page 2016]).
• Prostate cancer: Should rule out prostatic carcinoma before beginning therapy.
Concurrent drug therapy issues:
• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.
Blood pressure, standing and sitting/supine
Adverse events were observed in some animal reproduction studies. Prazosin crosses the placenta and its pharmacokinetics may be slightly altered during pregnancy (Bourget 1995; Rubin 1983). Limited use in pregnant women has not demonstrated any fetal abnormalities or adverse effects (Dommisse 1983).
Untreated chronic maternal hypertension is associated with adverse events in the fetus, infant, and mother. If treatment for hypertension during pregnancy is needed, other agents are generally preferred (ACOG 2013).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience fatigue, loss of strength and energy, headache, or nausea. Have patient report immediately to prescriber severe dizziness, passing out, blurred vision, tachycardia, arrhythmia, depression, shortness of breath, priapism, or swelling of arms or legs (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
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- Drug class: antiadrenergic agents, peripherally acting
Other brands: Minipress