Medically reviewed by Drugs.com. Last updated on Jul 13, 2019.
(LAN tha num)
- Lanthanum Carbonate
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Fosrenol: 750 mg (10 ea, 90 ea); 1000 mg (10 ea, 90 ea)
Tablet Chewable, Oral:
Fosrenol: 500 mg, 750 mg, 1000 mg
Generic: 500 mg, 750 mg, 1000 mg
Brand Names: U.S.
- Phosphate Binder
Disassociates in the upper gastrointestinal tract to lanthanum ions (La3+) which bind to dietary phosphate resulting in insoluble lanthanum phosphate complexes and a net decrease in serum phosphate and calcium levels.
Feces primarily; urine <2%
Plasma: 53 hours; Bone: 2-3.6 years
Use: Labeled Indications
Reduction of serum phosphorous: Reduction of serum phosphate in patients with end-stage renal disease (ESRD)
Bowel obstruction, fecal impaction, ileus
Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to lanthanum carbonate or any component of the formulation; hypophosphatemia
Reduction of serum phosphorous: Oral: Initial: 1,500 mg daily divided and taken with or immediately after meals; typical increases of 750 mg daily every 2 to 3 weeks are suggested as needed to reduce the serum phosphate level <6 mg/dL (1.92 mmol/L); usual dosage range: 1,500 to 3,000 mg daily; doses of up to 4,500 mg have been evaluated
Refer to adult dosing.
Administer with or immediately after meals.
Chewable tablet: Tablet should be chewed completely prior to swallowing; do not swallow whole. Tablet may be crushed to aid in chewing. Unchewed or incompletely chewed tablets may cause serious GI complications.
Oral powder: Sprinkle powder on a small quantity of applesauce or other similar food (not liquid) and administer immediately. Do not store for future use.
Take with or immediately after meals.
Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from moisture. Do not open oral powder until ready to use.
Ampicillin: Lanthanum may decrease the serum concentration of Ampicillin. Management: Administer oral ampicillin at least two hours before or after lanthanum. Consider therapy modification
Angiotensin-Converting Enzyme Inhibitors: Lanthanum may decrease the serum concentration of Angiotensin-Converting Enzyme Inhibitors. Management: Administer angiotensin-converting enzyme inhibitors at least two hours before or after lanthanum. Exceptions: Enalaprilat. Consider therapy modification
Antacids: May diminish the therapeutic effect of Lanthanum. Consider therapy modification
Bacampicillin: Lanthanum may decrease the serum concentration of Bacampicillin. Management: Administer bacampicillin at least 2 hours before or after lanthanum. Consider therapy modification
Chloroquine: Lanthanum may decrease the serum concentration of Chloroquine. Management: Administer chloroquine at least two hours before or after lanthanum. Consider therapy modification
Halofantrine: Lanthanum may decrease the serum concentration of Halofantrine. Management: Administer halofantrine at least two hours before or after lanthanum. Consider therapy modification
HMG-CoA Reductase Inhibitors (Statins): May decrease the serum concentration of Lanthanum. Management: Administer HMG-CoA reductase inhibitors at least two hours before or after lanthanum. Consider therapy modification
Quinolones: Lanthanum may decrease the serum concentration of Quinolones. Management: Administer oral quinolone antibiotics at least one hour before or four hours after lanthanum. Exceptions: Gemifloxacin; LevoFLOXacin (Oral Inhalation); Lomefloxacin. Consider therapy modification
Tetracyclines: Lanthanum may decrease the serum concentration of Tetracyclines. Management: Administer oral tetracycline antibiotics at least two hours before or after lanthanum. Exceptions: Eravacycline. Consider therapy modification
Thyroid Products: Lanthanum may decrease the serum concentration of Thyroid Products. Management: Administer oral thyroid products at least two hours before or after lanthanum. Consider therapy modification
Abdominal x-rays may have a radiopaque appearance.
Gastrointestinal: Diarrhea (oral powder: ≤18%; chewable tablets: ≤7%), nausea (oral powder: ≤18%; chewable tablet: ≤11%), vomiting (oral powder: ≤18%; chewable tablets: ≤9%)
1% to 10%:
Endocrine & metabolic: Hypocalcemia (5%)
Gastrointestinal: Abdominal pain (chewable tablet: 5%)
<1%, postmarketing, and/or case reports: Accidental injury (tooth injury with chewable tablets), allergic skin reaction, constipation, dyspepsia, fecal impaction, gastrointestinal perforation, hypophosphatemia, intestinal obstruction (including ileus and subileus), intestinal perforation
Concerns related to adverse effects:
• Gastrointestinal obstruction: Serious gastrointestinal (GI) obstruction, ileus, subileus, GI perforation, and fecal impaction have been reported, some requiring surgery or hospitalization. Risk factors include patients with altered GI anatomy (eg, diverticular disease, peritonitis, history of GI surgery, GI cancer, GI ulceration), hypomotility disorders (eg, constipation, ileus, subileus, diabetic gastroparesis), or medications known to potentiate effects; may also occur in patients without history of GI disease. Consider discontinuation in patients with unexplained severe GI symptoms.
• Biliary obstruction: Use with caution in patients with biliary obstruction (elimination of lanthanum may be reduced in these patients).
• Gastrointestinal disease: Use with caution in patients with active peptic ulcer, ulcerative colitis, or Crohn disease.
• Hepatic impairment: Use with caution in patients with hepatic impairment (elimination of lanthanum may be reduced in these patients).
Dosage form specific issues:
• Tablet: Chew thoroughly to decrease risk of serious adverse GI effects; do not swallow whole.
• Abdominal x-rays: May have a radiopaque appearance in patients taking lanthanum.
• Bone deposition: Rising lanthanum levels were observed in bone biopsies of patients treated for up to 4.5 years. Lanthanum deposits into developing bone, including growth plates; consequences on developing bone are not known. Use in children is not recommended.
Serum calcium, phosphorus, and parathyroid hormone (PTH): Frequency of measurement may be dependent upon the presence and magnitude of abnormalities, the rate of progression of chronic kidney disease (CKD), and the use of treatments for chronic kidney disease-mineral and bone disorder (CKD-MBD) (KDIGO 2017):
CKD stage G3a to G3b: Serum calcium and phosphate: Every 6 to 12 months; PTH: Frequency based on baseline level and progression of CKD
CKD stage G4: Serum calcium and phosphate: Every 3 to 6 months; PTH: Every 6 to 12 months
CKD stage G5 and G5D: Serum calcium and phosphate: Every 1 to 3 months; PTH: Every 3 to 6 months
Pregnancy Risk Factor
Adverse effects have been observed in some animal reproduction studies. The effect on absorption of vitamins and nutrients has not been studied. Lanthanum is not recommended for use during pregnancy.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience diarrhea, nausea, or vomiting. Have patient report immediately to prescriber severe abdominal pain or severe constipation (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
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- Drug class: phosphate binders
Other brands: Fosrenol