Medically reviewed by Drugs.com. Last updated on June 22, 2020.
(LAN tha num)
- Lanthanum Carbonate
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Fosrenol: 750 mg (10 ea, 90 ea); 1000 mg (10 ea, 90 ea)
Tablet Chewable, Oral:
Fosrenol: 500 mg, 750 mg, 1000 mg
Generic: 500 mg, 750 mg, 1000 mg
Brand Names: U.S.
- Phosphate Binder
Disassociates in the upper gastrointestinal tract to lanthanum ions (La3+) which bind to dietary phosphate resulting in insoluble lanthanum phosphate complexes and a net decrease in serum phosphate and calcium levels.
Feces primarily; urine <2%
Plasma: 53 hours; Bone: 2-3.6 years
Use: Labeled Indications
Reduction of serum phosphorous: Reduction of serum phosphate in patients with end-stage renal disease (ESRD)
Bowel obstruction, fecal impaction, ileus
Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to lanthanum carbonate or any component of the formulation; hypophosphatemia
Reduction of serum phosphorous: Oral: Initial: 1,500 mg daily divided and taken with or immediately after meals; typical increases of 750 mg daily every 2 to 3 weeks are suggested as needed to reduce the serum phosphate level <6 mg/dL (1.92 mmol/L); usual dosage range: 1,500 to 3,000 mg daily; doses of up to 4,500 mg have been evaluated.
Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
Refer to adult dosing.
Administer with or immediately after meals. Consider separating administration of oral medications from lanthanum when reduced bioavailability would significantly affect the concomitant medication's safety or efficacy; duration of separation varies based on absorption characteristics and whether it is an IR or ER product; monitor clinical response and/or blood concentrations of concomitant medications with a narrow therapeutic range.
Chewable tablet: Tablet should be chewed completely prior to swallowing; do not swallow whole. Tablet may be crushed to aid in chewing. Unchewed or incompletely chewed tablets may cause serious GI complications.
Oral powder: Sprinkle powder on a small quantity of applesauce or other similar food (not liquid) and administer immediately. Do not store for future use.
Take with or immediately after meals.
Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from moisture. Do not open oral powder until ready to use.
Ampicillin: Lanthanum may decrease the serum concentration of Ampicillin. Management: Administer oral ampicillin at least two hours before or after lanthanum. Consider therapy modification
Angiotensin-Converting Enzyme Inhibitors: Lanthanum may decrease the serum concentration of Angiotensin-Converting Enzyme Inhibitors. Management: Administer angiotensin-converting enzyme inhibitors at least two hours before or after lanthanum. Consider therapy modification
Antacids: May diminish the therapeutic effect of Lanthanum. Management: Administer antacid products at least 2 hours before or after lanthanum. Consider therapy modification
Bacampicillin: Lanthanum may decrease the serum concentration of Bacampicillin. Management: Administer bacampicillin at least 2 hours before or after lanthanum. Consider therapy modification
Chloroquine: Lanthanum may decrease the serum concentration of Chloroquine. Management: Administer chloroquine at least two hours before or after lanthanum. Consider therapy modification
Halofantrine: Lanthanum may decrease the serum concentration of Halofantrine. Management: Administer halofantrine at least two hours before or after lanthanum. Consider therapy modification
HMG-CoA Reductase Inhibitors (Statins): May decrease the serum concentration of Lanthanum. Management: Administer HMG-CoA reductase inhibitors at least two hours before or after lanthanum. Consider therapy modification
Quinolones: Lanthanum may decrease the serum concentration of Quinolones. Management: Administer oral quinolone antibiotics at least one hour before or four hours after lanthanum. Consider therapy modification
Tetracyclines: Lanthanum may decrease the serum concentration of Tetracyclines. Management: Administer oral tetracycline antibiotics at least two hours before or after lanthanum. Consider therapy modification
Thyroid Products: Lanthanum may decrease the serum concentration of Thyroid Products. Management: Separate the administration of thyroid products and lanthanum by at least 4 hours. Consider therapy modification
Abdominal x-rays may have a radiopaque appearance.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Gastrointestinal: Diarrhea (oral powder: ≤18%; chewable tablets: ≤7%), nausea (oral powder: ≤18%; chewable tablet: ≤11%), vomiting (oral powder: ≤18%; chewable tablets: ≤9%)
1% to 10%:
Endocrine & metabolic: Hypocalcemia (5%)
Gastrointestinal: Abdominal pain (chewable tablet: 5%)
<1%, postmarketing, and/or case reports: Accidental injury (tooth injury with chewable tablets), allergic skin reaction, constipation, dyspepsia, fecal impaction, gastrointestinal perforation, hypophosphatemia, intestinal obstruction (including ileus and subileus), intestinal perforation
Concerns related to adverse effects:
• GI obstruction: Serious GI obstruction, ileus, subileus, GI perforation, and fecal impaction have been reported, some requiring surgery or hospitalization. Risk factors include patients with altered GI anatomy (eg, diverticular disease, peritonitis, history of GI surgery, GI cancer, GI ulceration), hypomotility disorders (eg, constipation, ileus, subileus, diabetic gastroparesis), or medications known to potentiate effects; may also occur in patients without history of GI disease. Monitor patients closely for GI symptoms (eg, constipation, abdominal pain, abdominal distention); consider discontinuation in patients with unexplained severe GI symptoms.
• Biliary obstruction: Use with caution in patients with biliary obstruction (elimination of lanthanum may be reduced in these patients).
• Gastrointestinal disease: Use with caution in patients with active peptic ulcer, ulcerative colitis, or Crohn disease.
• Hepatic impairment: Use with caution in patients with hepatic impairment (elimination of lanthanum may be reduced in these patients).
Dosage form specific issues:
• Tablet: Chew thoroughly to decrease risk of serious adverse GI effects; do not swallow whole.
• Abdominal x-rays: Lanthanum has radio-opaque properties; may appear as an imaging agent on abdominal x-ray.
• Bone deposition: Rising lanthanum levels were observed in bone biopsies of patients treated for up to 4.5 years. Lanthanum deposits into developing bone, including growth plates; consequences on developing bone are not known. Use in children is not recommended.
Serum calcium, phosphorus, and parathyroid hormone (PTH): Frequency of measurement may be dependent upon the presence and magnitude of abnormalities, the rate of progression of chronic kidney disease (CKD), and the use of treatments for chronic kidney disease-mineral and bone disorder (CKD-MBD) (KDIGO 2017):
CKD stage G3a to G3b: Serum calcium and phosphate: Every 6 to 12 months; PTH: Frequency based on baseline level and progression of CKD
CKD stage G4: Serum calcium and phosphate: Every 3 to 6 months; PTH: Every 6 to 12 months
CKD stage G5 and G5D: Serum calcium and phosphate: Every 1 to 3 months; PTH: Every 3 to 6 months
Environmental studies suggest lanthanum may cross the placenta (Huo 2017).
If a reduction of serum phosphate is needed in pregnant patients with end-stage renal disease, agents other than lanthanum are preferred. Discontinuation of phosphate binders may be required in patients on intensified hemodialysis during pregnancy (Burgner 2019; Hladunewich 2016; Tangren 2018; Wiles 2019).
What is this drug used for?
• It is used to lower high phosphate levels.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
• Upset stomach
• Throwing up
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Severe stomach pain
• Severe constipation
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about lanthanum carbonate
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- Drug class: phosphate binders
Other brands: Fosrenol