Medically reviewed by Drugs.com. Last updated on Apr 4, 2020.
(er ith roe MYE sin)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Erygel: 2% (30 g, 60 g)
Generic: 2% (30 g, 60 g)
Ery: 2% (60 ea) [contains propylene glycol]
Generic: 2% (60 ea [DSC])
Generic: 2% (60 mL)
Brand Names: U.S.
- Acne Products
- Antibiotic, Macrolide
- Antibiotic, Topical
- Topical Skin Product
- Topical Skin Product, Acne
Antibacterial activity is due to inhibition of RNA-dependent protein synthesis at the chain elongation step; binds to the 50S ribosomal subunit resulting in blockage of transpeptidation. Alcohol component induces skin drying and peeling.
Use: Labeled Indications
Acne: Treatment of acne vulgaris
Note: The American Academy of Dermatology acne guidelines recommend erythromycin (topical) be used in conjunction with other therapies (not as monotherapy) due to the risk of bacterial resistance (AAD [Zaenglein 2016]).
Hypersensitivity to erythromycin or any component of the formulation
Documentation of allergenic cross-reactivity for erythromycin is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
Acne: Topical: Note: The American Academy of Dermatology acne guidelines recommend erythromycin (topical) be used in conjunction with other therapies (not as monotherapy) due to the risk of bacterial resistance (AAD [Zaenglein 2016]).
Gel: Apply sparingly as a thin film over the affected area once or twice daily. Therapeutic response may take up to 6 to 8 weeks; discontinue use if no improvement after 6 to 8 weeks or if condition worsens.
Ointment, solution: Apply to affected area twice daily (morning and evening); drying and peeling may be controlled by reducing the frequency of application.
Pads: Rub pad over affected areas twice daily (morning and evening); additional pads may be used, if needed.
Erysol [Canadian product]: Apply thin film to affected area twice daily (morning and evening after the skin has been thoroughly washed and patted dry); may decrease to once daily if irritation develops at application site. Therapeutic response may take up to 6 to 8 weeks; discontinue use if no improvement after 6 to 8 weeks or if condition worsens. Maximum therapy duration: 3 months
Refer to adult dosing.
Note: Akne-Mycin ointment has been discontinued in the US for more than 1 year.
Acne vulgaris: Limited data available (Eichenfield 2013): Note: Due to emerging resistance patterns, should not typically be used as monotherapy for the management of acne vulgaris (Eichenfield 2013; Zaenglein 2016). Children ≥7 years and Adolescents:
Gel: Apply as a thin film over the affected area once or twice daily. Therapeutic response may take several weeks (up to 6 to 8 weeks); discontinue use if no improvement after 6 to 8 weeks or if condition worsens
Ointment, solution: Apply over the affected area twice daily (morning and evening); drying and peeling may be controlled by reducing frequency of application
Pads (pledgets): Rub pad over affected area twice daily (morning and evening); additional pads may be used if needed
Topical: Prior to treatment, thoroughly wash affected area with mild soap and warm water, rinse, and pat dry. Discard pad after single use. Wash hands after use. Avoid contact with the eyes, nose, mouth and other mucous membranes, and broken skin.
Ery: Store at 20°C to 25°C (68°F to 77°F).
Erygel: Store at 20°C to 25°C (68°F to 77°F). Protect from heat and flame.
Erysol [Canadian product]: Store at 15°C to 30°C (59°F to 86°F). Protect from heat and flame.
Clindamycin (Topical): Erythromycin (Topical) may diminish the therapeutic effect of Clindamycin (Topical). Avoid combination
Isotretinoin (Topical): May enhance the adverse/toxic effect of Erythromycin (Topical). Monitor therapy
Frequency not defined.
Dermatologic: Desquamation, erythema, exfoliation of skin, oily skin, pruritus, rough skin (leather appearance), skin fissure (around mouth), skin tenderness, urticaria, xeroderma
Local: Application site irritation (includes local dryness, localized burning, localized erythema, localized tenderness, stinging of the skin)
Ophthalmic: Eye irritation
<1%, postmarketing and/or case reports: Abdominal distress, abdominal pain, diarrhea, facial edema, hypersensitivity reaction, skin rash
Concerns related to adverse effects:
• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment. Discontinue if significant diarrhea, abdominal cramps, or passage of blood and mucus occurs.
Concurrent drug therapy issues:
• Concurrent topical acne therapy: Use with caution especially with peeling, desquamating or abrasive agents; irritation may be cumulative. Discontinue use if irritation or dermatitis occurs.
Dosage form specific issues:
• Topical gel: May be flammable. Keep away from heat and flame.
• Appropriate use: For topical use only; not for ophthalmic use. Avoid contact with eyes, nose, mouth, mucous membranes, or broken skin. Lack of improvement or worsening of acne may indicate microbial resistance. Alternative therapy may be required for severe acne (eg, nodular). Consider alternate therapy in patients with poor tolerance to macrolides or clindamycin. In the treatment of acne, American Academy of Dermatology acne guidelines recommend erythromycin (topical) be used in conjunction with other therapies (not as monotherapy) due to the risk of bacterial resistance. If given for mild acne, erythromycin (topical) should be used in combination with benzoyl peroxide. If given for moderate to severe acne, it should be used in combination with a topical retinoid or systemic antibiotic agent (AAD [Zaenglein 2016]).
The amount of erythromycin available systemically following topical application is considered to be very low (Akhavan 2003). Systemic absorption would be required in order for erythromycin to cross the placenta and reach the fetus.
Topical erythromycin may be used for the treatment of acne in pregnancy (AAD [Zaenglein 2016]; Eichenfield 2013).
What is this drug used for?
• It is used to treat pimples (acne).
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
• Dry skin
• Skin irritation
• Oily skin
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Eye irritation
• Colitis like abdominal pain or cramps, severe diarrhea or watery stools, or bloody stools
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about erythromycin topical
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Pricing & Coupons
- En Español
- 1 Review
- Drug class: topical acne agents
- Erythromycin topical (AHFS Monograph)
- Erythromycin Gel (FDA)
- Erythromycin Pledgets (FDA)
- Erythromycin Topical Solution (FDA)