Medically reviewed by Drugs.com. Last updated on May 30, 2019.
(bas i TRAY sin)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Reconstituted, Intramuscular:
BACiiM: 50,000 units (1 ea)
Generic: 50,000 units (1 ea)
Solution Reconstituted, Intramuscular [preservative free]:
BACiiM: 50,000 units (1 ea)
Generic: 50,000 units (1 ea)
Brand Names: U.S.
- Antibiotic, Miscellaneous
Inhibits bacterial cell wall synthesis by preventing transfer of mucopeptides into the growing cell wall
Rapidly following IM administration
Widely distributed in all body organs and is demonstrable in ascitic and pleural fluids after IM injection
Use: Labeled Indications
Pneumonia and empyema: Treatment of pneumonia and empyema in infants caused by susceptible staphylococci; due to toxicity risks, systemic uses of bacitracin should be limited to situations where less toxic alternatives would not be effective
Hypersensitivity to bacitracin or any component of the formulation
Pneumonia and empyema; staphylococcal: Note: Due to toxicity risks, systemic use of bacitracin should be limited to situations where less toxic alternatives would not be effective; systemic use in pediatric patients is rare. Do not administer IV:
≤2.5 kg: 900 units/kg/day in 2 to 3 divided doses
>2.5 kg: 1000 units/kg/day in 2 to 3 divided doses
Solution for injection (IM use only): Store unreconstituted vials in the refrigerator at 2°C to 8°C (36°F to 46°F). Once reconstituted, bacitracin is stable for 1 week under refrigeration at 2°C to 8°C (36°F to 46°F).
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination
Colistimethate: May enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy
Neomycin: May enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination
Neuromuscular-Blocking Agents: Bacitracin (Systemic) may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
Polymyxin B: May enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
Streptomycin: May enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination
Frequency not defined.
Dermatologic: Skin rash
Endocrine & metabolic: Albuminuria
Gastrointestinal: Nausea, vomiting
Genitourinary: Azotemia, casts in urine, nephrotoxicity
Local: Pain at injection site
Renal: Renal failure
Postmarketing and/or case reports: Anaphylaxis (intraoperative exposure [Damm, 2011])
ALERT: U.S. Boxed WarningNephrotoxicity:
Bacitracin in parenteral (IM) therapy may cause renal failure due to tubular and glomerular necrosis. Its use should be restricted to infants with staphylococcal pneumonia and empyema when due to organisms shown to be susceptible to bacitracin. It should be used only where adequate laboratory facilities are available and when constant supervision of the patient is possible.
Renal function should be carefully determined prior to and daily during therapy. The recommended daily dose should not be exceeded, and fluid intake and urinary output should be maintained at proper levels to avoid kidney toxicity. If renal toxicity occurs the drug should be discontinued. The concurrent use of other nephrotoxic drugs, particularly streptomycin, kanamycin, polymyxin B, polymyxin E (colistin), and neomycin should be avoided.
Concerns related to adverse effects:
• Anaphylaxis: Use with caution in patients who have been previously exposed to bacitracin; anaphylactic reactions have occurred on repeat exposure especially with irrigation use (Damm 2011; Elsner 1990; Farley 1995).
• Renal failure: [US Boxed Warning]: IM use may cause renal failure due to tubular and glomerular necrosis; monitor renal function daily. Avoid concurrent use with other nephrotoxic drugs; discontinue use if toxicity occurs; maintain adequate fluid intake and urine output throughout therapy. Do not exceed recommended doses.
• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.
• Appropriate use: Do not administer intravenously because severe thrombophlebitis occurs.
• Monitoring: Should only be used when adequate laboratory facilities are available and constant patient supervision is available.
IM: Urinalysis, renal function tests, urine output
This product is not indicated for use in women of reproductive age.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience injection site pain. Have patient report immediately to prescriber signs of kidney problems (urinary retention, hematuria, change in amount of urine passed, or weight gain), signs of Clostridium difficile (C. diff)-associated diarrhea (abdominal pain or cramps, severe diarrhea or watery stools, or bloody stools), severe nausea, or vomiting (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about bacitracin
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- Drug class: miscellaneous antibiotics
Other brands: BACiiM