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Tobramycin (injection)

Generic name: tobramycin (injection) [ toe-bra-MYE-sin ]
Brand name: Tobramycin Sulfate ADD-Vantage injection
Dosage forms: injectable powder for injection (1.2 g), injectable solution (10 mg/mL; 40 mg/mL)
Drug classes: Aminoglycosides, Inhaled anti-infectives

Medically reviewed by Drugs.com on Aug 2, 2023. Written by Cerner Multum.

What is tobramycin injection?

Tobramycin is an aminoglycoside (ah-meen-oh-GLY-ko-side) antibiotic. Tobramycin fights infections that are caused by bacteria.

Tobramycin injection is used to treat bacterial infections of the skin, heart, stomach, brain and spinal cord, lungs, and urinary tract (bladder and kidneys). It is also used in the treatment of cystic fibrosis. Tobramycin injection is sometimes used together with other antibiotics.

Tobramycin may also be used for purposes not listed in this medication guide.

Tobramycin injection side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tobramycin can damage nerves and may cause hearing loss that may be permanent. Tell your doctor right away if you have:

Tobramycin may cause serious side effects. Call your doctor at once if you have:

Common side effects of tobramycin may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Tobramycin can damage nerves and may cause hearing loss that may be permanent.

Call your doctor right away if you have numbness, tingling, muscle twitching, dizziness, spinning sensation, seizure (convulsions), hearing loss, or a ringing or roaring sound in your ears (even after you have stopped using tobramycin injection).

Tobramycin can also harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Tell your doctor about all other medications you use, especially injected antibiotics.

Before taking this medicine

You should not use this medication if you are allergic to tobramycin or similar antibiotics (amikacin, gentamicin, kanamycin, neomycin, paromomycin, streptomycin).

To make sure tobramycin injection is safe for you, tell your doctor if you have:

FDA pregnancy category D. Do not use tobramycin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Tobramycin can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Serious side effects may be more likely in older adults.

How should I use tobramycin injection?

Follow all directions on your prescription label. Do not use tobramycin in larger or smaller amounts or for longer than recommended.

Tobramycin is injected into a muscle, or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Drink 6 to 8 full glasses of water each day while you are using tobramycin injection. You may become easily dehydrated while using this medication.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Tobramycin will not treat a viral infection such as the common cold or flu.

Your doctor will need to check your hearing and kidney function while you are using tobramycin.

If you need surgery, tell the surgeon ahead of time that you are using tobramycin injection. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

amoxicillin, doxycycline, ciprofloxacin, cephalexin, azithromycin, metronidazole, triamcinolone, ceftriaxone, clindamycin, Augmentin

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tobramycin injection?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect tobramycin injection?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with tobramycin, especially:

Tobramycin can harm your kidneys. This effect is increased when you also use certain other medicines, especially:

This list is not complete. Other drugs may interact with tobramycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Does tobramycin interact with my other drugs?

Enter other medications to view a detailed interaction report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.