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Rifamate

Generic Name: isoniazid and rifampin (eye so NYE a zid and RIF am pin)
Brand Name: IsonaRif, Rifamate

Medically reviewed on January 15, 2018

What is Rifamate?

Rifamate are antibiotics that fight bacteria.

Rifamate is a combination medicine used to treat tuberculosis (TB).

Rifamate may also be used for purposes not listed in this medication guide.

Important Information

You should not use Rifamate if you have active liver disease (including hepatitis or cirrhosis), or a history of liver problems caused by taking isoniazid.

Serious and sometimes fatal liver problems may occur during treatment with Rifamate or after you stop taking this medication, even months after stopping. The risk of liver problems is highest in adults between the ages of 35 and 65. Your liver function may need to be checked every month while you are taking Rifamate.

Call your doctor right away if you have: nausea, upper stomach pain, loss of appetite, and unusual weakness or tiredness.

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking Rifamate.

Before taking this medicine

You should not use this medicine if you are allergic to isoniazid or rifampin, or if you have active liver disease (including hepatitis or cirrhosis), or a history of liver problems caused by taking isoniazid.

To make sure Rifamate is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • diabetes;

  • gout;

  • seizures; or

  • if you drink alcohol every day.

Serious and sometimes fatal liver problems may occur during treatment with Rifamate or after you stop taking this medication, even months after stopping. The risk of liver problems is highest in adults between the ages of 35 and 65. Your liver function may need to be checked every month while you are taking this medicine.

It is not known whether Rifamate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Rifamate can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking this medicine.

Isoniazid and rifampin can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Rifamate?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Rifamate.

Follow all directions on your prescription label. Do not take Rifamate in larger or smaller amounts or for longer than recommended.

Take Rifamate on an empty stomach, at least 1 hour before or 2 hours after a meal.

Rifamate may cause temporary discoloration of your teeth, sweat, urine, saliva, and tears (a yellow, orange, red, or brown color). This side effect is usually not harmful. However, soft contact lenses may be permanently stained if you wear them while taking this medicine.

Dark colored urine can be a sign of liver problems. Call your doctor if you have reddish-brown urine together with upper stomach pain, loss of appetite, and jaundice (yellowing of your skin or eyes).

Your doctor may have you take extra vitamin B6 while you are taking Rifamate. Take only the amount of vitamin B6 that your doctor has prescribed.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Rifamate will not treat a viral infection such as the common cold or flu.

Rifamate is usually given until lab tests show that the infection has cleared.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Rifamate.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Rifamate?

Avoid wearing contact lenses. Rifamate may discolor your tears, which could permanently stain soft contact lenses.

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking Rifamate.

Rifamate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • nausea, upper stomach pain, feeling weak or tired, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • vision changes, confusion, hallucinations, unusual thoughts or behavior;

  • fever, unusual weakness, pale skin; or

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Rifamate?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with isoniazid and rifampin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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