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Rifampin and isoniazid (Oral)

rif-AM-pin, eye-soe-NYE-a-zid

Oral route(Capsule)

Severe and sometimes fatal hepatitis has been reported with isoniazid therapy and may occur even after many months of treatment. The risk for hepatitis generally increases with advancing age and alcohol use. Monthly clinical evaluation and liver function tests should be performed. Instruct patients to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid should be discontinued promptly. If isoniazid must be reinstituted, it should be reinstituted only after symptoms and laboratory abnormalities have cleared. The drug should be restarted in very small and gradually increasing doses and should be withdrawn immediately if there is any indication of recurrent liver involvement. Treatment should be deferred in persons with acute hepatic diseases .

Medically reviewed by Drugs.com. Last updated on May 18, 2019.

Commonly used brand name(s)

In the U.S.

  • IsonaRif
  • Rifamate

Available Dosage Forms:

  • Capsule

Therapeutic Class: Antitubercular Combination

Chemical Class: Rifamycin

Uses for rifampin and isoniazid

Rifampin and isoniazid combination is used to treat tuberculosis (TB) infection. It may be taken alone or with one or more other medicines for TB. Rifampin belongs to the class of medicines called antibiotics and works to kill or prevent the growth of bacteria. However, it will not work for colds, flu, or other virus infections.

Rifampin and isoniazid is available only with your doctor's prescription.

Before using rifampin and isoniazid

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rifampin and isoniazid, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to rifampin and isoniazid or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of rifampin and isoniazid combination in children younger than 15 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rifampin and isoniazid combination in the elderly.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rifampin and isoniazid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using rifampin and isoniazid with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Artemether
  • Atazanavir
  • Bictegravir
  • Boceprevir
  • Cobicistat
  • Daclatasvir
  • Darunavir
  • Dasabuvir
  • Delamanid
  • Doravirine
  • Elagolix
  • Elbasvir
  • Elvitegravir
  • Fosamprenavir
  • Glecaprevir
  • Grazoprevir
  • Isavuconazonium
  • Lopinavir
  • Lorlatinib
  • Lurasidone
  • Maraviroc
  • Nelfinavir
  • Ombitasvir
  • Paritaprevir
  • Pibrentasvir
  • Praziquantel
  • Ranolazine
  • Rilpivirine
  • Ritonavir
  • Saquinavir
  • Sofosbuvir
  • Telaprevir
  • Tenofovir Alafenamide
  • Tipranavir
  • Velpatasvir
  • Voriconazole
  • Voxilaprevir

Using rifampin and isoniazid with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abemaciclib
  • Abiraterone Acetate
  • Acalabrutinib
  • Acetaminophen
  • Afatinib
  • Alfentanil
  • Alpelisib
  • Amifampridine
  • Amiodarone
  • Amlodipine
  • Amprenavir
  • Apixaban
  • Apremilast
  • Aprepitant
  • Aripiprazole
  • Atovaquone
  • Avatrombopag
  • Axitinib
  • Bedaquiline
  • Bendamustine
  • Benzhydrocodone
  • Betrixaban
  • Bosutinib
  • Brexpiprazole
  • Brigatinib
  • Brivaracetam
  • Buprenorphine
  • Bupropion
  • Cabozantinib
  • Carbamazepine
  • Cariprazine
  • Ceritinib
  • Cholera Vaccine, Live
  • Clozapine
  • Cobimetinib
  • Codeine
  • Copanlisib
  • Crizotinib
  • Cyclosporine
  • Dabigatran Etexilate
  • Darolutamide
  • Dasatinib
  • Deferasirox
  • Deflazacort
  • Delavirdine
  • Desogestrel
  • Dexamethasone
  • Dienogest
  • Digoxin
  • Dihydrocodeine
  • Dolutegravir
  • Domperidone
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Drospirenone
  • Duvelisib
  • Edoxaban
  • Efavirenz
  • Elexacaftor
  • Eliglustat
  • Eluxadoline
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eravacycline
  • Erdafitinib
  • Erlotinib
  • Estradiol
  • Ethinyl Estradiol
  • Ethionamide
  • Ethynodiol
  • Etonogestrel
  • Etravirine
  • Everolimus
  • Exemestane
  • Fedratinib
  • Fentanyl
  • Fosaprepitant
  • Fosnetupitant
  • Fosphenytoin
  • Fostamatinib
  • Gefitinib
  • Gestodene
  • Gilteritinib
  • Glasdegib
  • Glimepiride
  • Halothane
  • Hemin
  • Hydrocodone
  • Ibrutinib
  • Idelalisib
  • Ifosfamide
  • Imatinib
  • Indinavir
  • Irinotecan
  • Irinotecan Liposome
  • Isoniazid
  • Istradefylline
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ixazomib
  • Ketoconazole
  • Lamotrigine
  • Lapatinib
  • Larotrectinib
  • Ledipasvir
  • Lefamulin
  • Letermovir
  • Levodopa
  • Levonorgestrel
  • Linagliptin
  • Lorcainide
  • Macimorelin
  • Macitentan
  • Manidipine
  • Meperidine
  • Mestranol
  • Methadone
  • Metoprolol
  • Midostaurin
  • Mifepristone
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Naloxegol
  • Neratinib
  • Netupitant
  • Nevirapine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Olaparib
  • Osimertinib
  • Oxcarbazepine
  • Oxycodone
  • Palbociclib
  • Paliperidone
  • Panobinostat
  • Pazopanib
  • Pentazocine
  • Perampanel
  • Pexidartinib
  • Phenytoin
  • Piperaquine
  • Pitavastatin
  • Pitolisant
  • Ponatinib
  • Posaconazole
  • Pretomanid
  • Pyrazinamide
  • Quetiapine
  • Quinine
  • Regorafenib
  • Revefenacin
  • Ribociclib
  • Rifampin
  • Rivaroxaban
  • Roflumilast
  • Rolapitant
  • Romidepsin
  • Simeprevir
  • Siponimod
  • Sirolimus
  • Sonidegib
  • Sorafenib
  • Stiripentol
  • Sufentanil
  • Tacrolimus
  • Tamoxifen
  • Tasimelteon
  • Tegafur
  • Telithromycin
  • Temsirolimus
  • Tezacaftor
  • Thiotepa
  • Ticagrelor
  • Tofacitinib
  • Tolvaptan
  • Trabectedin
  • Tramadol
  • Ulipristal
  • Upadacitinib
  • Valbenazine
  • Vandetanib
  • Vemurafenib
  • Venetoclax
  • Vilazodone
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Vorapaxar
  • Vortioxetine
  • Voxelotor
  • Zanubrutinib

Using rifampin and isoniazid with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Aliskiren
  • Aminosalicylic Acid
  • Anisindione
  • Aripiprazole Lauroxil
  • Atorvastatin
  • Betamethasone
  • Bexarotene
  • Bosentan
  • Buspirone
  • Carbamazepine
  • Carvedilol
  • Caspofungin
  • Chloramphenicol
  • Chlorpropamide
  • Citalopram
  • Clarithromycin
  • Clofibrate
  • Cortisone
  • Diazepam
  • Dicumarol
  • Diltiazem
  • Disopyramide
  • Disulfiram
  • Doxycycline
  • Eltrombopag
  • Enalaprilat
  • Enalapril Maleate
  • Enflurane
  • Etoricoxib
  • Fluconazole
  • Fludrocortisone
  • Fosphenytoin
  • Gliclazide
  • Glyburide
  • Haloperidol
  • Isradipine
  • Levomethadyl
  • Levothyroxine
  • Linezolid
  • Losartan
  • Mefloquine
  • Meperidine
  • Metformin
  • Methylprednisolone
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nisoldipine
  • Ospemifene
  • Phenprocoumon
  • Phenytoin
  • Pioglitazone
  • Pirmenol
  • Prednisolone
  • Prednisone
  • Propafenone
  • Raltegravir
  • Repaglinide
  • Risperidone
  • Rofecoxib
  • Rosiglitazone
  • Sertraline
  • Simvastatin
  • Tadalafil
  • Theophylline
  • Tocainide
  • Triazolam
  • Trimetrexate
  • Valproic Acid
  • Warfarin
  • Zaleplon
  • Zidovudine
  • Zolpidem

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using rifampin and isoniazid with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use rifampin and isoniazid, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Using rifampin and isoniazid with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use rifampin and isoniazid, or give you special instructions about the use of food, alcohol, or tobacco.

  • food
  • Tyramine Containing Food

Other medical problems

The presence of other medical problems may affect the use of rifampin and isoniazid. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, or history of—Use with caution. There may be an increased chance of getting liver problems if you take rifampin and isoniazid and drink alcohol daily.
  • Blood clotting problems or
  • Diabetes, history of or
  • Porphyria (an enzyme problem) or
  • Seizures or
  • Vitamin K deficiency—Use with caution. May make these conditions worse.
  • Gout, acute or
  • Liver disease, acute or severe or
  • Meningococcal disease (including infections of the lining of the brain and spinal cord [meningitis] and blood stream [eg, bacteremia, septicemia])—Should not be used in patients with these conditions.
  • Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Liver disease, chronic or
  • Patients with poor nutrition status—Use with caution. May increase risk for vitamin K deficiency, which may lead to excessive bleeding.

Proper use of rifampin and isoniazid

Take rifampin and isoniazid only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Rifampin and isoniazid should be taken on an empty stomach, 1 hour before or 2 hours after a meal, with a full of glass of water. It is important to take rifampin and isoniazid on a regular schedule.

If rifampin and isoniazid upsets your stomach, take it with food. Antacids may also help. However, do not take aluminum-containing antacids (eg, Maalox®, Mylanta®) within 1 hour of the time you take rifampin and isoniazid combination. They may keep rifampin and isoniazid from working properly.

To help clear up your tuberculosis (TB) infection completely, it is very important that you keep taking rifampin and isoniazid for the full time of treatment, even if you begin to feel better after a few weeks. It is important that you do not miss any doses.

Your doctor may also want you to take pyridoxine (eg, Hexa-Betalin, vitamin B6) every day to help prevent or lessen some of the side effects of isoniazid. If it is needed, it is very important to take pyridoxine everyday along with rifampin and isoniazid. Do not miss any doses.

If you are taking itraconazole, do not use rifampin and isoniazid combination 2 weeks before and during itraconazole treatment.

Dosing

The dose of rifampin and isoniazid will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rifampin and isoniazid. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the oral dosage form (capsules):
    • For the treatment of tuberculosis:
      • Adults and children 15 years of age and older weighing 55 kilograms (kg)—2 capsules (containing 600 milligrams (mg) of rifampin and 300 mg of isoniazid) once a day.
      • Children younger than 15 years of age—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of rifampin and isoniazid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If rifampin and isoniazid combination is taken on an irregular schedule, side effects may occur more often and may be more serious than usual. If you have any questions about this, check with your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using rifampin and isoniazid

It is very important that your doctor check your or your child's progress at regular visits. Blood and urine tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

Do not use rifampin and isoniazid if you are also receiving certain medicines to treat HIV infection (eg, atazanavir, darunavir, fosamprenavir, ritonavir, saquinavir, tipranavir, Aptivus®, Fortovase®, Invirase®, Lexiva®, Norvir®, Prezista®, or Reyataz®).

Do not use rifampin and isoniazid together with praziquantel. If you need to take praziquantel, you should stop using rifampin and isoniazid 4 weeks before starting praziquantel. You may restart rifampin and isoniazid one day after the last dose of praziquantel.

Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking rifampin and isoniazid. Also, the regular use of alcohol may keep rifampin and isoniazid from working properly. Therefore, you should strictly limit the amount of alcoholic beverages you drink while you are taking rifampin and isoniazid.

Check with your doctor right away if you or your child have a fever, chills, cough, sore throat, swollen, painful, or tender lymph glands in the neck, armpit, or groin, or yellow skin or eyes while using rifampin and isoniazid. These could be symptoms of a serious condition called drug reaction with eosinophilia and systemic symptoms (DRESS).

Serious skin reactions can occur with rifampin and isoniazid. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with rifampin and isoniazid.

Check with your doctor right away if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you or your child to have your eyes checked by an ophthalmologist (eye doctor).

Do not stop using rifampin and isoniazid suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

Check with your doctor right away if you have joint pain, stiffness, or swelling, lower back, side, or stomach pain, or swelling of the feet or lower legs. These could be symptoms of an acute gout.

Rifampin and isoniazid will cause urine, stool, saliva, sputum, sweat, teeth, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are using rifampin and isoniazid. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. It is best not to wear soft contact lenses while using rifampin and isoniazid. Hard contact lenses are not discolored by rifampin and isoniazid. This condition will return to normal once you stop using rifampin and isoniazid. If you have any questions about this, check with your doctor.

Check with your doctor right away if you feel very tired or very weak, or if you have clumsiness, unsteadiness, loss of appetite, nausea, numbness, tingling, burning, or pain in the hands and feet, or vomiting. These may be early warning symptoms of more serious liver or nerve problems that could develop later.

Rifampin and isoniazid combination may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.

Before you have any medical tests, tell the medical doctor in charge that you are using rifampin and isoniazid. The results of some tests may be affected by rifampin and isoniazid.

Eating certain foods (eg, Cheshire cheese, Swiss cheese, skipjack, tuna, or Sardinella) or drinking red wine may cause reactions in some patients taking isoniazid-containing medicines. Check with your doctor if flushing, fast or pounding heartbeat, headache, red or itching skin, sweating, dizziness, or lightheadedness occur while you are taking rifampin and isoniazid.

Birth control pills may not work properly while you are using rifampin and isoniazid. To keep from getting pregnant, use another form of birth control along with your birth control pills. Other forms include condoms, diaphragms, or contraceptive foams or jellies.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Rifampin and isoniazid side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Clumsiness or unsteadiness
  • dark urine
  • loss of appetite
  • nausea and vomiting
  • numbness, tingling, burning, or pain in the hands and feet
  • unusual tiredness or weakness
  • yellow eyes or skin

Less common

  • Chills
  • difficult breathing
  • dizziness
  • fever
  • headache
  • itching, skin rash and redness
  • muscle and bone pain
  • shivering

Rare

  • Bloody or cloudy urine
  • blurred vision or loss of vision, with or without eye pain
  • convulsions (seizures)
  • depression
  • greatly decreased frequency of urination or amount of urine
  • mood or mental changes
  • sore throat
  • unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • stomach pain or upset

Less common

  • Sore mouth or tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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