Generic Name: diclofenac topical (dye KLOE fen ak TOP ik al)
Brand Name: Pennsaid, Rexaphenac, Solaraze, Voltaren Topical
What is Rexaphenac?
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID).
Rexaphenac (for the skin) is used to treat joint pain caused by osteoarthritis. Rexaphenac is for use on the hands, wrists, elbows, knees, ankles, or feet. This medicine may not be effective in treating arthritis pain elsewhere in the body.
Pennsaid is for use only on the knees.
Solaraze is used to treat warty overgrowths of skin (actinic keratoses) on sun-exposed areas of the body.
Rexaphenac may also be used for purposes not listed in this medication guide.
Rexaphenac can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). This medicine may also cause stomach or intestinal bleeding, which can be fatal.
Before taking this medicine
Rexaphenac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use Rexaphenac just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Rexaphenac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.
You should not use this medicine if you are allergic to diclofenac (Voltaren, Cataflam, Flector, and others), or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Rexaphenac is not approved for use by anyone younger than 18 years old.
Tell your doctor if you have ever had:
a heart attack, stroke, or blood clot;
stomach ulcers, bleeding in your stomach or intestines;
liver or kidney disease; or
Diclofenac can affect ovulation and it may be harder to get pregnant while you are using this medicine.
If you are pregnant, you should not take Rexaphenac unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How should I use Rexaphenac?
Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.
Do not take by mouth. Topical medicine is for use only on the skin. Rinse with water if this medicine gets in your eyes or mouth.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Do not apply Rexaphenac to an open skin wound, or on areas of infection, rash, burn, or peeling skin.
Store at room temperature away from moisture and heat. Do not freeze.
What happens if I miss a dose?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Rexaphenac?
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen).
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid exposing treated skin to heat, sunlight, or tanning beds. Heat can increase the amount of diclofenac you absorb through your skin.
Avoid getting Rexaphenac in your eyes. If contact does occur, rinse with water. Call your doctor if you have eye irritation that lasts longer than 1 hour.
Do not use cosmetics, sunscreen, lotions, insect repellant, or other medicated skin products on the same area you treat with Rexaphenac.
Rexaphenac side effects
Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing or trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Although the risk of serious side effects is low when diclofenac is applied to the skin, this medicine can be absorbed through the skin, which may cause steroid side effects throughout the body.
Stop using diclofenac and seek emergency medical attention if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Also call your doctor at once if you have:
a skin rash, no matter how mild;
swelling, rapid weight gain;
severe headache, blurred vision, pounding in your neck or ears;
little or no urination;
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.
Common side effects may include:
headache, dizziness, drowsiness;
itching, increased sweating;
increased blood pressure; or
skin redness, itching, dryness, scaling, or peeling where the medicine was applied.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Rexaphenac?
Ask your doctor before using diclofenac if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your current medicines, especially:
heart or blood pressure medication, including a diuretic or "water pill"; or
steroid medicine (prednisone and others).
This list is not complete and many other drugs may affect diclofenac. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
More about diclofenac topical
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- 429 Reviews
- Drug class: topical non-steroidal anti-inflammatories
- FDA Alerts (1)
- Patient Information
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- Diclofenac Topical (Advanced Reading)
- Diclofenac Cream
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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