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Porfimer

Generic name: porfimer [ POR-fi-mer ]
Brand name: Photofrin
Dosage form: intravenous powder for injection (75 mg)
Drug class: Malignancy photosensitizers

Medically reviewed by Drugs.com on Jul 22, 2024. Written by Cerner Multum.

What is porfimer?

Porfimer is used together with "photodynamic" laser light therapy to reduce the size of tumors in the lungs or esophagus (the tube that connects your mouth and stomach).

Porfimer may also be used for purposes not listed in this medication guide.

Porfimer side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Porfimer may cause serious side effects. Call your doctor at once if you have:

Common side effects of porfimer may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not receive porfimer if you have porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system), esophageal bleeding, a fistula (abnormal passageway) in the throat or esophagus, or a tumor that affects a large blood vessel.

Before taking this medicine

You should not receive porfimer if you are allergic to it, or if you have:

Tell your doctor if you have ever had:

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Porfimer can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 5 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using porfimer.

Do not breastfeed while using this medicine, and for at least 5 months after your last dose.

How is porfimer given?

Porfimer is given as an infusion into a vein. A healthcare provider will give you this injection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when porfimer is injected.

You will receive laser light treatment within 40 to 50 hours after your porfimer infusion. A second laser light treatment may be given within 96 to 120 hours after your infusion.

Porfimer will make your skin and eyes more sensitive to sunlight. For at least 30 days after you are treated with porfimer, you must protect your eyes and skin from natural sunlight and bright indoor lights (such as lights in a doctor's office, operating room lamps, tanning beds, bright halogen lights, or unshaded light bulbs).

Keep all parts of your skin covered with clothing and wear dark sunglasses when you are outdoors. Sunscreen will not protect you from severe sunburn during the 30-day period after your treatment with porfimer.

Your sensitivity to light may last for up to 90 days or longer. Ask your doctor to determine if your skin is still sensitive to sunlight.

Exposure to sunlight shining through a window is not as harmful and can help your body eliminate porfimer. Follow your doctor's instructions about the best amount of light exposure.

You may need frequent medical tests or a biopsy every 3 months.

If you need major surgery or will be on long-term bed rest, you may need to stop using porfimer for a short time. Any doctor or surgeon who treats you should know that you are being treated with porfimer.

Opdivo, methotrexate, Keytruda, pembrolizumab, cisplatin, capecitabine, Avastin, Xeloda, nivolumab, Herceptin

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your laser light therapy. The timing between your porfimer injection and your light therapy is important for the treatment to be effective.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving porfimer?

Avoid exposure to sunlight or bright indoor lights for at least 90 days after you are treated with porfimer.

Porfimer may cause your eyes to be more sensitive to oncoming headlights while you are driving. Avoid driving at night until this effect wears off.

What other drugs will affect porfimer?

Porfimer can make your skin more sensitive to sunlight. This effect may be increased when you also use certain other medicines, including: antibiotics, heart or blood pressure medication, certain anti-psychotic medication, or medicine to control severe nausea and vomiting.

Other drugs may affect porfimer, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does porfimer interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.