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Plegridy

Generic Name: peginterferon beta-1a (peg in ter FEAR on BAY ta - 1A)
Brand Name: Plegridy

What is peginterferon beta-1a?

Peginterferon beta-1a is made from human proteins. Interferons stimulate the body's immune responses to infection or disease.

Peginterferon beta-1a is used to treat relapsing multiple sclerosis (MS). This medicine will not cure MS, it will only decrease the frequency of relapse symptoms.

Peginterferon beta-1a may also be used for purposes not listed in this medication guide.

What is the most important information I should know about peginterferon beta-1a?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before using peginterferon beta-1a?

You should not use peginterferon beta-1a if you are allergic to peginterferon or other interferons (Alferon, Avonex, Betaseron, Extavia, Intron, Rebetron, Rebif, and others).

To make sure peginterferon beta-1a is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • heart disease;

  • a history of depression, mental illness, or suicidal thoughts or actions;

  • a bleeding or blood clotting disorder;

  • a thyroid disorder;

  • epilepsy or other seizure disorder; or

  • an autoimmune disorder such as rheumatoid arthritis, lupus, or psoriasis.

FDA pregnancy category C. It is not known whether peginterferon beta-1a will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether peginterferon beta-1a passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Peginterferon beta-1a is not approved for use by anyone younger than 18 years old.

How is peginterferon beta-1a given?

Peginterferon beta-1a is usually given once every 2 weeks. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Peginterferon beta-1a is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

Use a different place on your stomach, thigh, or upper arm each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

About 2 hours after your injection, check for skin redness, swelling, or pain where you gave the injection.

Call your doctor if you have a skin reaction to peginterferon beta-1a that does not go away within a few days.

Peginterferon beta-1a can cause flu-like symptoms. Your doctor may recommend taking a pain reliever or fever reducer such as aspirin, acetaminophen (Tylenol), or ibuprofen (Advil, Motrin) on the days you receive your injections.

While using peginterferon beta-1a, you may need frequent blood tests.

Store prefilled syringes or injection pens in their original container in the refrigerator. Keep the carton closed and always protect the medicine from light.

Do not freeze peginterferon beta-1a, and throw away the medicine if it has become frozen.

About 30 minutes before your injection, take the syringe or pen out of the refrigerator and allow it to reach room temperature. Do not warm the medicine under hot water.

If you do not have access to a refrigerator, store peginterferon beta-1a at cool room temperature and return it to a refrigerator when possible. This medicine should not be out of a refrigerator for longer than a total of 30 days.

Each single-use prefilled syringe or injection pen is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using peginterferon beta-1a?

Avoid injecting this medicine into skin that is red, bruised, irritated, scarred, or infected.

Peginterferon beta-1a side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching, bumps on your skin; feeling anxious or light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • seizure (convulsions);

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;

  • a light-headed feeling, like you might pass out;

  • chest pain or pressure, fast or irregular heart rate;

  • mood or behavior changes, anxiety, irritability, new or worsening depression, thoughts about suicide or hurting yourself;

  • pain, burning, irritation, or skin changes where the injection was given;

  • low blood platelets--easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  • low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • signs of an autoimmune disorder--joint pain, tremors, weight loss, skin sores, mouth sores, hair loss, butterfly-shaped facial rash, numbness or tingling, blood or mucus in your stools, being more sensitive to hot or cold temperatures.

Common side effects may include:

  • itching or skin redness where the injection was given;

  • flu symptoms (fever, chills, body aches);

  • muscle or joint pain;

  • headache; or

  • weakness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect peginterferon beta-1a?

Other drugs may interact with peginterferon beta-1a, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about peginterferon beta-1a.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01. Revision Date: 2014-10-30, 3:08:23 PM.

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