Plegridy Side Effects
Generic name: peginterferon beta-1a
Medically reviewed by Drugs.com. Last updated on May 29, 2022.
Note: This document contains side effect information about peginterferon beta-1a. Some of the dosage forms listed on this page may not apply to the brand name Plegridy.
Common side effects of Plegridy include: arthralgia, asthenia, fever, flu-like symptoms, headache, myalgia, chills, erythema at injection site, pain at injection site, and swelling at injection site. Other side effects include: suicidal ideation, hyperthermia, increased serum alanine aminotransferase, pruritus, vomiting, decreased white blood cell count, depression, increased serum aspartate aminotransferase, and increased body temperature. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to peginterferon beta-1a: solution
Side effects requiring immediate medical attention
Along with its needed effects, peginterferon beta-1a (the active ingredient contained in Plegridy) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking peginterferon beta-1a:
- Blue-green to black skin discoloration
- extremely high fever or body temperature
- fast, shallow breathing
- fast, weak heartbeat
- general feeling of discomfort or illness
- joint pain
- muscle aches, cramps, and pains
- pale, clammy skin
- runny nose
- sore throat
- trouble sleeping
- unusual tiredness or weakness
- Dark urine
- decreased appetite
- itching skin
- light-colored stools
- stomach pain
- yellow eyes or skin
- Chest tightness
- difficulty with swallowing
- hives or welts, skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the skin
Side effects not requiring immediate medical attention
Some side effects of peginterferon beta-1a may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Difficulty with moving
- itching, rash, redness, soreness, swelling, or warmth at the injection site
- lack or loss of strength
- muscle aches, cramps, pains, or stiffness
- pain, redness, or sloughing of the skin at the injection site
For Healthcare Professionals
Applies to peginterferon beta-1a: intramuscular solution, subcutaneous kit, subcutaneous solution
Frequency not reported: Decreased peripheral blood counts[Ref]
Common (1% to 10%): Alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl-transferase increased
Frequency not reported: hepatic injury[Ref]
Very common (10% or more): Influenza like illness (47%)
Very common (10% or more): Injection site erythema (62%), injection site pain (15%), injection site pruritus (13%)
Very common (10% or more): Myalgia (19%), arthralgia (11%)[Ref]
Very common (10% or more): Headache (44%)
Uncommon (0.1% to 1%): Seizures[Ref]
Very common (10% or more): Pyrexia (45%), chills (17%), asthenia (13%)
Common (1% to 10%): Hyperthermia, pain[Ref]
Frequently asked questions
- What are the new drugs used for multiple sclerosis (MS)?
- What is Plegridy used for and is it an immunosuppressant?
- How do you use the Plegridy pen and where do you inject?
More about Plegridy (peginterferon beta-1a)
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (12)
- Patient tips
- Pricing & coupons
- En español
- Drug class: interferons
- FDA approval history
- Drug Information
- Plegridy Pen (Advanced Reading)
- Plegridy Pen Starter Pack (Advanced Reading)
- Plegridy Starter Pack
Related treatment guides
1. "Product Information. Plegridy (peginterferon beta-1a)." Biogen Idec Inc (2014):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.