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Generic Name: mitomycin (MYE toe MYE sin)
Brand Name: Mutamycin

What is Mutamycin?

Mutamycin is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Mutamycin is used in combination with other cancer medications to treat cancer of the stomach and pancreas.

Mutamycin treats only the symptoms of stomach or pancreatic cancer but does not treat the cancer itself.

Mutamycin may also be used for purposes not listed in this medication guide.

Important Information

Mutamycin can weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness).

Mutamycin can also damage red blood cells, which may cause irreversible kidney failure. Call your doctor right away if you have unusual bruising or bleeding, pale skin, confusion, tiredness or irritability, stomach pain, bloody diarrhea, red or pink urine, swelling, rapid weight gain, and little or no urinating.

Before taking this medicine

You should not use Mutamycin if you are allergic to it, or if you have:

  • bleeding or blood clotting disorder such as hemophilia;

  • bone marrow suppression; or

  • active bleeding or any risk of bleeding.

To make sure Mutamycin is safe for you, tell your doctor if you have:

Using Mutamycin during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.

Mitomycin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How is mitomycin given?

Mutamycin is injected into a vein through an IV. A healthcare provider will give you this injection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Mutamycin is injected.

Some people receiving Mutamycin have developed ulcers on the skin where an injection was given, or on other areas of body. Skin changes may occur several weeks or months after a this medicine injection. Call your doctor if you notice any redness, sores, oozing, or other skin changes during or after your treatment with this medicine.

Mutamycin can weaken (suppress) your immune system, and you may get an infection more easily. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. This medicine can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medication.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Mutamycin injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Mutamycin?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Do not receive a "live" vaccine while using Mutamycin, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Mutamycin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mutamycin can damage red blood cells, which may cause irreversible kidney failure. Call your doctor right away if you have:

  • pale skin, unusual bruising or bleeding;

  • confusion, tiredness or irritability;

  • stomach pain, bloody diarrhea, red or pink urine;

  • swelling, rapid weight gain; or

  • little or no urinating.

Call your doctor at once if you have:

  • signs of infection (fever, weakness, cold or flu symptoms, skin sores, frequent or recurring illness);

  • wheezing, chest tightness, new or worsening cough, trouble breathing;

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or

  • pain, burning, redness, irritation, or skin changes where the injection was given.

Common side effects may include:

  • fever or other signs of infection;

  • nausea, vomiting, diarrhea, loss of appetite;

  • mouth sores;

  • drowsiness, headache;

  • blurred vision; or

  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Mutamycin?

Other drugs may interact with mitomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Mutamycin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01.

Last reviewed: August 29, 2017
Date modified: February 01, 2018