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Padcev

Generic Name: enfortumab vedotin (en FORT ue mab ve DOE tin)
Brand Names: Padcev

Medically reviewed by Judith Stewart, BPharm Last updated on Apr 22, 2020.

What is Padcev?

Padcev (enfortumab vedotin) is an anticancer medicine that affects the growth and cell division of cancer cells.

Padcev a prescription medicine used to treat cancer of the bladder or urinary tract in adults.

Padcev is used when the cancer is advanced, has spread to other parts of the body (metastatic), or cannot be removed with surgery.

Padcev is usually given after other treatments such as immunotherapy or platinum cancer medicine.

Important Information

Before receiving Padcev, tell your healthcare provider about all of your medical conditions, including if you are currently experiencing numbness or tingling in your hands or feet, have a history of high blood sugar or diabetes, or are pregnant or plan to become pregnant. Enfortumab vedotin can harm your unborn baby.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

To make sure Padcev is safe for you, tell your doctor if you have:

  • numbness or tingling in your hands or feet;

  • diabetes; or

  • high blood sugar.

Enfortumab vedotin can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, do not use Padcev if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Padcev.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because enfortumab vedotin can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 3 weeks after your last dose.

How is Padcev given?

Padcev is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 30 minutes to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Padcev is injected.

Padcev is given in a 28-day treatment cycle. You may need to use the medicine only on certain days of each cycle. Your doctor will determine how long to treat you with this medicine.

Padcev can cause high blood sugar (hyperglycemia) even if you have never had it before or if you are not diabetic. Severe hyperglycemia may be life-threatening. Your blood sugar may need to be checked often.

Padcev can also cause dry eyes. Your doctor may tell you to use artificial-tear eye drops to help prevent dry eyes.

Padcev dosing information

Usual Adult Dose for Urothelial Carcinoma:

1.25 mg/kg (up to a maximum of 125 mg for patients 100 kg or greater) IV over 30 minutes on Days 1, 8. and 15 of a 28-day cycle until disease progression or unacceptable toxicity

Use: For locally advanced or metastatic urothelial cancer (mUC) who have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor, and a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced or metastatic setting

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Padcev injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Padcev?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Padcev side effects

Get emergency medical help if you have signs of an allergic reaction to Padcev: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have symptoms of high blood sugar:

  • increased thirst, dry mouth, fruity breath odor;

  • increased urination,

  • confusion, drowsiness; or

  • nausea, vomiting, stomach pain, loss of appetite.

Also call your doctor at once if you have:

  • numbness, tingling, or burning pain in your hands or feet;

  • pain, redness, and peeling skin on your hands or feet;

  • a severe skin rash with itching, scaling, or blisters;

  • severely dry eyes, vision problems; or

  • redness, itching, swelling, or discomfort where the medicine was injected.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Padcev side effects may include:

  • numbness or tingling;

  • muscle weakness;

  • feeling tired;

  • nausea, loss of appetite, diarrhea;

  • rash, dry skin;

  • hair loss; or

  • changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Padcev?

Some drugs can affect your blood levels of enfortumab vedotin, which may increase side effects. Tell your doctor about all your other medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Padcev only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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