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Ipilimumab

Generic Name: ipilimumab (IP i LIM ue mab)
Brand Name: Yervoy

Medically reviewed on April 23, 2018

What is ipilimumab?

See also: Xeloda

Ipilimumab is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Ipilimumab is used to treat melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body. Ipilimumab is also used to prevent melanoma from coming back after surgery, including lymph node removal.

Ipilimumab is also used to treat kidney cancer, sometimes given with another medicine called nivolumab (Opdivo).

Ipilimumab may also be used for purposes not listed in this medication guide.

Important Information

Serious and sometimes fatal reactions may occur during treatment with ipilimumab, or months after stopping. Call your doctor right away if you have symptoms such as: stomach pain, black or bloody stools, dark urine, yellowing of your skin or eyes, neck stiffness, muscle weakness, numbness or tingling, headache, confusion, vision problems, trouble with daily activities, chest pain, shortness of breath, or blistering or peeling of your skin.

Before taking this medicine

You should not receive ipilimumab if you are allergic to it.

Tell your doctor if you have ever had:

Ipilimumab may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using ipilimumab and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

In animal studies, ipilimumab caused miscarriage, premature delivery, low birth weight, stillbirth, and infant death. However, it is not known whether these effects would occur in humans. Ask your doctor about your risk.

You should not breast-feed while you are receiving ipilimumab and for at least 3 months after your last dose.

Ipilimumab is not approved for use by anyone younger than 12 years old.

How is ipilimumab given?

Ipilimumab is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take up to 90 minutes to complete.

Ipilimumab is usually given once every 3 weeks for up to 4 doses. Additional doses may be given once every 2 to 12 weeks. Follow your doctor's dosing instructions very carefully.

You may be given other medications to treat or prevent certain side effects.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ipilimumab injection.

What happens if I overdose?

Since ipilimumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving ipilimumab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Ipilimumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, itchy, warm, tingly, feverish, chilled, or light-headed.

Serious and sometimes fatal reactions may occur during treatment with ipilimumab or months after stopping. Call your doctor right away if you have symptoms such as:

  • diarrhea, black or bloody stools, stomach pain or tenderness;

  • dark urine, jaundice (yellowing of the skin or eyes);

  • neck stiffness, headache, feeling cold or tired;

  • mood changes, dizziness, drowsiness, confusion, hallucinations;

  • a seizure;

  • memory problems, trouble with daily activities;

  • muscle weakness, numbness or tingling;

  • chest pain, cough, feeling short of breath;

  • mouth sores, skin rash, blistering or peeling of the skin; or

  • eye pain or vision problems.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • fever, cough;

  • nausea, diarrhea, loss of appetite, weight loss;

  • rash or itching;

  • headache, tiredness; or

  • pain in your muscles, joints, or bones.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect ipilimumab?

Other drugs may affect ipilimumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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