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Hexatrione (injection)

Generic name: triamcinolone (injection) [ TRYE-am-SIN-oh-lone ]
Brand names: Hexatrione, Kenalog-10, Kenalog-40, Kenalog-80, Zilretta
Drug class: Glucocorticoids

Medically reviewed by on Aug 8, 2023. Written by Cerner Multum.

What is Hexatrione?

Hexatrione is a steroid medicine that is used to treat many different types of inflammatory conditions, including severe allergic reactions, skin disorders, severe colitis, inflammation of the joints or tendons, blood cell disorders, inflammatory eye disorders, lung disorders, and problems caused by low adrenal gland hormones.

Hexatrione is also used to treat certain skin disorders caused by autoimmune conditions such as lupus, psoriasis, lichen planus, and others.

Different brands of triamcinolone injection have different uses.

Hexatrione may also be used for purposes not listed in this medication guide.

Hexatrione side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Hexatrione may cause serious side effects. Call your doctor at once if you have:

  • (after injection into a joint space) increased pain or swelling, joint stiffness, fever, and general ill feeling;

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;

  • unusual changes in mood or behavior;

  • swelling, rapid weight gain, feeling short of breath;

  • stomach cramps, vomiting, diarrhea, bloody or tarry stools, rectal irritation;

  • sudden numbness or weakness (especially on one side of the body);

  • a seizure (convulsions);

  • severe headache, blurred vision, pounding in your neck or ears;

  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or

  • signs of low adrenal gland hormones--flu-like symptoms, headache, depression, weakness, tiredness, diarrhea, vomiting, stomach pain, craving salty foods, and feeling light-headed.

Certain side effects may be more likely with long-term use or repeated doses of triamcinolone injection.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Hexatrione.

Common side effects of Hexatrione may include:

  • skin changes (acne, dryness, redness, bruising, discoloration);

  • increased hair growth, or thinning hair;

  • nausea, bloating, appetite changes;

  • stomach or side pain;

  • cough, runny or stuffy nose;

  • headache, sleep problems (insomnia);

  • a wound that is slow to heal;

  • sweating more than usual; or

  • changes in your menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You may not be able to receive this medicine if you have a fungal infection, or a condition called idiopathic thrombocytopenic purpura (ITP).

Before taking this medicine

You should not be treated with Hexatrione if you are allergic to it.

You may not be able to receive Hexatrione if you have a fungal infection, or a condition called idiopathic thrombocytopenic purpura (ITP).

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is Hexatrione given?

Hexatrione is given through a needle and can be injected into different areas of the body: into a muscle, into the space around a joint or tendon, or into a lesion on the skin. A healthcare provider will give you this injection.

Not every brand of Hexatrione is used for the same conditions or injected into the same body areas. Some brands are given only one time as needed. Others may be given at regular intervals. Carefully follow your doctor's dosing instructions.

Hexatrione can weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, weakness, cold or flu symptoms, skin sores, diarrhea, frequent or recurring illness).

Long-term use of steroids can cause harmful effects on the eyes. If you receive Hexatrione for longer than 6 weeks, your doctor may want you to have regular eye exams.

Your doctor may instruct you to limit your salt intake while you are receiving Hexatrione. You may also need to take potassium supplements. Follow all instructions.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Hexatrione.

You should not stop using Hexatrione suddenly after long-term repeated use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for a scheduled Hexatrione.

When Hexatrione is used as a single dose, you will not be on a regular dosing schedule.

What happens if I overdose?

Since Hexatrione is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Using too much Hexatrione is not likely to cause serious problems. However, long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while receiving Hexatrione?

After injection of triamcinolone into a joint, avoid overusing that joint through strenuous activity or high-impact sports. You could cause damage to the joint.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Hexatrione.

Do not receive a "live" vaccine or a toxoid vaccine while using Hexatrione, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine. Toxoid vaccines include diphtheria-tetanus toxoid (DT or Td).

What other drugs will affect Hexatrione?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect Hexatrione, especially:

This list is not complete and many other drugs may affect Hexatrione. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.