Medically reviewed on August 3, 2018
The Granulex brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
What is balsam Peru, castor oil, and trypsin?
Balsam Peru increases blood flow to a wound area, and also helps fight bacteria.
Castor oil prevents skin cells from breaking down, which aids in wound healing.
Trypsin helps to strip away (or slough off) damaged skin cells.
Granulex (for the skin) is a combination medicine used to treat bed sores and other skin ulcers. This medication can help promote healing and relieve pain caused by these conditions.
Balsam Peru, castor oil, and trypsin may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use Granulex if you are allergic to balsam Peru, castor oil, or trypsin.
This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether this medicine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I use balsam Peru, castor oil, and trypsin?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Do not take by mouth. Topical medicine is for use only on the skin. Do not get this medicine in your eyes or nose. Avoid inhaling the spray.
Wash your hands before and after applying this medicine.
Apply a thin layer of medication to the wound. Balsam Peru, castor oil, and trypsin is usually applied 2 or 3 times daily. Follow your doctor's instructions.
Shake the spray form of this medicine before each use. Hold the can about 12 inches from your skin and spray enough medicine to coat the wound.
After applying the medicine, you may cover the wound with a bandage dressing, or leave the wound open to the air. Your doctor will tell you whether you should cover the wound or not.
If you need to remove the medicine, gently wash it off with water.
Some forms of this medicine are flammable. Do not use near open flame or while you are smoking. Do not smoke until the medicine has completely dried on your skin.
Use this medication regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Store at room temperature away from moisture and heat. Do not allow the medicine to freeze.
Keep the spray canister away from open flame or high heat. The canister may explode if it gets too hot. Do not puncture or burn an empty spray canister.
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
An overdose of balsam Peru, castor oil, and trypsin is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.
What should I avoid while using balsam Peru, castor oil, and trypsin?
Avoid getting Granulex in your eyes, mouth, nose, or on your lips. If it does get into any of these areas, rinse with water.
Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.
Avoid using other medications on the areas you treat with balsam Peru, castor oil, and trypsin unless your doctor tells you to.
Balsam Peru, castor oil, and trypsin side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Treating a skin wound may increase your risk of developing an infection. Call your doctor at once if you have any signs of infection, such as:
fever or chills;
rapid heart rate;
mouth and throat ulcers;
rapid and shallow breathing;
warmth or redness under your skin; or
a light-headed feeling, like you might pass out.
Less serious side effects are more likely, such as mild stinging or burning where the medicine is applied.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect balsam Peru, castor oil, and trypsin?
It is not likely that other drugs you take orally or inject will have an effect on topically applied balsam Peru, castor oil, and trypsin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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