Generic Name: fulvestrant (ful VES trant)
Brand Name: Faslodex
What is fulvestrant?
Fulvestrant is used to treat advanced hormone-related breast cancer in women. Fulvestrant is sometimes used if your cancer tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.
Fulvestrant may also be used when the cancer has progressed or has spread to other parts of the body after treatment with anti-estrogen medication.
Fulvestrant may also be given together with another medicine (either abemaciclib or palbociclib) to treat advanced HER2-negative breast cancer that has progressed or spread.
Fulvestrant may also be used for purposes not listed in this medication guide.
You should not receive fulvestrant if you are pregnant.
Avoid getting pregnant or breast-feeding a baby for at least 1 year after you stop using fulvestrant.
Before taking this medicine
You should not be treated with fulvestrant if you are allergic to it, or if you are pregnant.
Tell your doctor if you have ever had:
a bleeding or blood clotting disorder; or
thrombocytopenia (a low level of platelets in the blood).
Using fulvestrant during pregnancy could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 year after your treatment ends. Tell your doctor right away if you become pregnant during this time.
It is not known whether fulvestrant passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How is fulvestrant given?
Fulvestrant is given as two injections into a muscle of your buttock. Your doctor, nurse, or other healthcare provider will give you this injection.
Each injection must be given slowly, and can take up to 2 minutes to complete.
Fulvestrant is usually given once every 2 weeks at first, and then once a month. Do not miss any scheduled appointments.
When treatment also includes taking abemaciclib or palbociclib, these medicines are taken by mouth and have different dosing schedules. Palbociclib is also taken with food while abemaciclib may be taken with or without food. Follow your doctor's dosing instructions very carefully.
If you are a woman using fulvestrant with palbociclib, tell your doctor if you are going through menopause (you have symptoms such as irregular menstrual periods, hot flashes, night sweats, or vaginal dryness). You may need to be treated with an additional hormone medication.
Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.
fulvestrant can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using fulvestrant.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your fulvestrant injection.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving fulvestrant?
fulvestrant can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Fulvestrant side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
signs of nerve damage--numbness, tingling, weakness, or burning pain.
Common side effects may include:
bone pain, joint pain, muscle pain;
weakness, feeling tired;
cough, sore throat, sinus problems, trouble breathing;
abnormal liver function tests;
hot flashes; or
pain where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Fulvestrant dosing information
Usual Adult Dose for Breast Cancer:
500 mg IM into the buttocks (gluteal area) slowly (1 to 2 minutes per injection) as two 5 mL injections, one in each buttock, on days 1, 15, 29 and once monthly thereafter
In combination with palbociclib or abemaciclib: 500 mg IM into the buttocks (gluteal area) slowly (1 to 2 minutes per injection) as two 5 mL injections, one in each buttock, on days 1, 15, 29 and once monthly thereafter
-This drug is not recommended for use in men.
-When this drug is used in combination with palbociclib, the recommended dose of palbociclib is 125 mg orally once daily for 21 consecutive days followed by 7 days off therapy for a complete cycle of 28 days. Palbociclib should be taken with food. Refer to the prescribing information for palbociclib.
-When this drug is used in combination with abemaciclib, the recommended dose of abemaciclib is 150 mg orally 2 times a day. Abemaciclib may be taken with or without food. Refer to the prescribing information for abemaciclib.
-Pre- or peri-menopausal women treated with the combination of this drug plus palbociclib or abemaciclib should be treated with luteinizing hormone-releasing hormone (LHRH) agonists according to current guidelines.
-As monotherapy for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in postmenopausal women not previously treated with endocrine therapy or HR-positive advanced breast cancer in postmenopausal women with disease progression following endocrine therapy
-For HR-positive, HER2-negative advanced or metastatic breast cancer in combination with palbociclib or abemaciclib in women with disease progression after endocrine therapy
What other drugs will affect fulvestrant?
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect fulvestrant, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 9.01.
More about fulvestrant
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 9 Reviews
- Drug class: estrogen receptor antagonists
Other brands: Faslodex