Fulvestrant Dosage

Usual Adult Dose for Breast Cancer

Initial dose: 500 mg IM on days 1, 15, and 29, then once a month thereafter.

Renal Dose Adjustments

CrCl 30 mL/min or more: No adjustment recommended

CrCl 29 mL/min or less: Data not available

Liver Dose Adjustments

Mild liver function (Child-Pugh class A): No specific dose adjustment guidelines have been suggested; however, caution is recommended.

Moderate liver dysfunction (Child-Pugh class B): 250 mg IM on days 1, 15, and 29, then once a month thereafter.

Severe liver dysfunction (Child-Pugh class C): Data not available

Precautions

Women of childbearing age should be advised not to become pregnant while receiving fulvestrant.

Because fulvestrant is administered intramuscularly it should be used with caution in patients with bleeding diatheses, thrombocytopenia, or patients on anticoagulants.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

In patients with normal renal and hepatic function, fulvestrant should be administered as two 250 mg injections, one in each buttock, by slow intramuscular injection (1 to 2 minutes per injection).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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