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Generic Name: cefiderocol ( SEF i DER oh kol)
Brand Name: Fetroja

Medically reviewed by on Jan 4, 2021. Written by Cerner Multum.

What is Fetroja?

Fetroja is a cephalosporin (SEF-a-lo-SPOR-in) antibiotic.

Fetroja is used to treat serious bladder or kidney infections in adults.

Fetroja is also used to treat adults who have developed pneumonia while being in a hospital or using a ventilator.

Fetroja can cause serious or life-threatening allergic reactions. Fetroja should be used only for infections that cannot be treated with a safer antibiotic.

Fetroja may also be used for purposes not listed in this medication guide.


You should not use Fetroja if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic (Omnicef, Keflex, and others).

Before taking this medicine

You should not use Fetroja if you have ever had a severe allergic reaction to Fetroja or to certain antibiotics, such as:

Tell your doctor if you have ever had:

  • an allergy to any drug (especially penicillin);

  • kidney disease (or if you are on dialysis);

  • a seizure

  • liver disease; or

  • intestinal problems, such as colitis.

Tell your doctor if you are pregnant or breastfeeding.

How is Fetroja given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Fetroja is sometimes given for up to 14 days.

Fetroja is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

This medicine must be given slowly, and the infusion can take at least 3 hours to complete.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Fetroja must be mixed with a liquid (diluent) and then further diluted with another liquid in an IV bag. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Fetroja will not treat a viral infection such as the flu or a common cold.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Fetroja.

Store unmixed Fetroja in the original carton in a refrigerator. Protect from light and do not freeze.

After mixing Fetroja with a diluent, keep the vial at room temperature and further dilute it within 1 hour. After diluting the mixture into an IV bag, keep the bag at room temperature and use it within 6 hours.

Each IV bag is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Fetroja?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Fetroja side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

  • tremor, rigid muscles, or a seizure;

  • white patches or sores inside your mouth or on your lips; or

  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fetroja?

Other drugs may affect Fetroja, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.