Epinephrine nasal
Generic name: epinephrine nasal [ EP-i-NEF-rin ]
Brand name: Neffy
Dosage form: nasal spray (1 mg/0.1 mL; 2 mg/0.1 mL)
Drug classes: Adrenergic bronchodilators, Catecholamines, Vasopressors
What is epinephrine nasal?
Epinephrine nasal is used to treat severe allergic reactions (anaphylaxis) in adults and children at least 4 years old who weigh at least 33 pounds (15 kg).
Epinephrine nasal may also be used for purposes not listed in this medication guide.
Epinephrine nasal side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Common side effects of epinephrine nasal may include:
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nasal discomfort;
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throat irritation;
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headache, tiredness, dizziness;
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nausea, vomiting;
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cold symptoms such as stuffy nose, sneezing, sore throat;
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chest and nasal congestion; or
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feeling overly excited, nervous, or anxious.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Related/similar drugs
Warnings
Do not use epinephrine nasal if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.
Always carry your epinephrine nasal with you. Allergic emergency can happen anytime. Make sure any person caring for you knows where you keep epinephrine nasal and how to use it.
Before taking this medicine
Do not use epinephrine nasal if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.
Tell your doctor if you have ever had:
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nasal problem including past surgeries;
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heart problems;
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kidney problems;
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low blood potassium;
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diabetes.
It is not known if epinephrine nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are breastfeeding.
Serious side effects may be more likely in older adults.
How should I take epinephrine nasal?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Epinephrine nasal is for the nose inhalation only. Don't spray it in your mouth or eyes.
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Each device contains 1 dose. Do not test or spray it before using.
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Use one spray in one nostril. If symptoms don't improve or get worse after 5 minutes, use the second device in the same nostril.
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Do not sniff while or after using it.
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Always carry two devices with you in case a second dose is needed.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Epinephrine nasal is used when needed.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking epinephrine nasal?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What other drugs will affect epinephrine nasal?
Ask a doctor or pharmacist before using epinephrine inhalation with any other medications, especially:
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a diuretic or "water pill";
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parkinson's medications;
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heart medication; or
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medicine to treat depression.
This list is not complete and many other drugs may affect epinephrine nasal. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Popular FAQ
Can you use an expired EpiPen in an emergency?
If someone is having an anaphylactic reaction, and all you have on hand is a recently expired EpiPen, then use it so long as it is not discolored and does not contain any particles. There is minimal risk in using a recently expired EpiPen, but the benefits are significant. But check the clear viewing window of the pen and if you notice it is discolored or contains particles then don’t use it as the solution may have oxidized, making it less effective. Continue reading
Can you bring an EpiPen on a plane?
You can bring your EpiPen onto a plane – they are a common medical device and they should not cause any fuss when you are going through airport security. You can carry them in your handbag, laptop bag, or other carry-on luggage. It is a very good idea to take your EpiPen with you on the plane because the small confines of an aircraft increase your odds of being exposed to a trigger allergen while you are flying and having an anaphylactic reaction. Continue reading
What's the mechanism of action for epinephrine?
Epinephrine works by activating both alpha and beta receptors found in your body in response to a severe allergy (called anaphylaxis). By acting on alpha receptors, it helps to maintain your blood pressure and heart function, and by acting on beta receptors, it relaxes your lung airways to help relieve shortness of breath and wheezing. Continue reading
Does epinephrine cause vasoconstriction?
Yes, epinephrine causes vasoconstriction (tightening of the blood vessels). This results in increased blood pressure. Continue reading
How much does Auvi-Q cost compared to EpiPen?
The cash price for a 2-pack of Auvi-Q autoinjector is around $300 compared to $650 for an EpiPen 2-pack. Prices can vary depending upon the pharmacy you visit and if you have any coupons or manufacturer discounts. Auvi-Q and EpiPen are brand names for epinephrine autoinjectors. Continue reading
How does neffy work?
Neffy works in the same way as epinephrine injections, activating both alpha and beta receptors to narrow blood vessels. This helps to maintain blood pressure and heart function, and relaxes smooth muscles in the airways of the lungs to make breathing easier. neffy may also relax the smooth muscles of the stomach and intestine to relieve digestive symptoms often associated with anaphylaxis, such as nausea. Continue reading
More FAQ
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Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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