Generic name: epinephrine nasal [ EP-i-NEF-rin ]
Brand name: Neffy
Dosage form: nasal spray (1 mg/0.1 mL; 2 mg/0.1 mL)
Drug classes: Adrenergic bronchodilators, Catecholamines, Vasopressors

Medically reviewed by Drugs.com on Jun 10, 2025. Written by Cerner Multum.

What is epinephrine nasal?

Epinephrine nasal is used to treat severe allergic reactions (anaphylaxis) in adults and children at least 4 years old who weigh at least 33 pounds (15 kg).

Epinephrine nasal may also be used for purposes not listed in this medication guide.

Epinephrine nasal side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Common side effects of epinephrine nasal may include:

• nasal discomfort;

• throat irritation;

• headache, tiredness, dizziness;

• nausea, vomiting;

• cold symptoms such as stuffy nose, sneezing, sore throat;

• chest and nasal congestion; or

• feeling overly excited, nervous, or anxious.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Do not use epinephrine nasal if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Always carry your epinephrine nasal with you. Allergic emergency can happen anytime. Make sure any person caring for you knows where you keep epinephrine nasal and how to use it.

Before taking this medicine

Do not use epinephrine nasal if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Tell your doctor if you have ever had:

• nasal problem including past surgeries;

• heart problems;

• kidney problems;

• low blood potassium;

• parkinson's disease;

• high blood pressure; or

• diabetes.

It is not known if epinephrine nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Tell your doctor if you are breastfeeding.

Serious side effects may be more likely in older adults.

How should I take epinephrine nasal?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Epinephrine nasal is for the nose inhalation only. Don't spray it in your mouth or eyes.

• Each device contains 1 dose. Do not test or spray it before using.

• Use one spray in one nostril. If symptoms don't improve or get worse after 5 minutes, use the second device in the same nostril.

• Do not sniff while or after using it.

• Always carry two devices with you in case a second dose is needed.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Epinephrine nasal is used when needed.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking epinephrine nasal?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect epinephrine nasal?

Ask a doctor or pharmacist before using epinephrine inhalation with any other medications, especially:

• a diuretic or "water pill";

• parkinson's medications;

• heart medication; or

• medicine to treat depression.

This list is not complete and many other drugs may affect epinephrine nasal. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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