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DermacinRx Lexitral PharmaPak (topical)

Generic name: capsaicin and diclofenac (topical) [ kap-SAY-i-sin-and-dye-KLOE-fen-ak-TOP-ik-al ]
Brand names: DermacinRx Lexitral PharmaPak, Diclotral Pak
Drug class: Topical non-steroidal anti-inflammatories

Medically reviewed by on Jan 5, 2024. Written by Cerner Multum.

What is DermacinRx Lexitral PharmaPak?

Capsaicin is the active ingredient in chili peppers that makes them hot. Capsaicin is used in medicated creams and lotions to relieve muscle or joint pain.

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID).

DermacinRx Lexitral PharmaPak (for the skin) is a combination medicine used to treat joint pain, stiffness, and swelling caused by osteoarthritis of the knees. DermacinRx Lexitral PharmaPak may not be effective in treating arthritis pain elsewhere in the body.

DermacinRx Lexitral PharmaPak may also be used for purposes not listed in this medication guide.

DermacinRx Lexitral PharmaPak side effects

Get emergency medical help if you have signs of an allergic reaction (sneezing, runny or stuffy nose, hives, wheezing or trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Serious side effects are unlikely when DermacinRx Lexitral PharmaPak is applied to the skin, but can occur if the medicine is absorbed into your bloodstream.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

Common side effects of DermacinRx Lexitral PharmaPak may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Diclofenac can increase your risk of fatal heart attack or stroke. Do not use DermacinRx Lexitral PharmaPak just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac may also cause stomach or intestinal bleeding, which can be fatal.

Before taking this medicine

Diclofenac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Diclofenac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using DermacinRx Lexitral PharmaPak, especially in older adults.

You should not use this medicine if you are allergic to capsaicin or diclofenac, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

If you are pregnant, you should not use DermacinRx Lexitral PharmaPak unless your doctor tells you to. Using an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

This medicine is not approved for use by anyone younger than 18 years old.

How should I use DermacinRx Lexitral PharmaPak?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. DermacinRx Lexitral PharmaPak is for use only on the skin. If this medicine gets in your eyes, nose, or mouth, rinse with water.

Do not apply to open wounds or to sunburned, chapped, irritated, or infected skin. Do not cover treated skin with a bandage or expose it to heat from a hot tub, heating pad, or sauna.

Apply the solution only to clean, dry skin. Spread the solution over the front, back, and sides of the knee.

Wash your hands after applying this medicine. Wait at least 30 minutes before you bathe or shower.

Wait until the solution is completely dry before covering treated skin with clothing or applying any other skin products (cosmetics, sunscreen, lotions, insect repellant, or other medicated skin products).

Do not allow others to touch the area where you have applied the medicine.

Capsaicin can cause a burning sensation wherever it is applied. This sensation is usually mild and should gradually lessen over time with continued regular use of the medicine.

If the burning sensation is painful or causes significant discomfort, wash the treated skin area with soap and cool water. Get medical attention right away if you have severe burning, pain, swelling, or blistering.

If you use this medicine long-term, you may need frequent medical tests.

Call your doctor if your arthritis symptoms do not improve after 7 days of treatment, or if your symptoms get better and then worse within a few days.

Store at room temperature away from moisture and heat.

DermacinRx Lexitral PharmaPak solution is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

What happens if I miss a dose?

Since DermacinRx Lexitral PharmaPak is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222, especially if anyone has accidentally swallowed it.

What should I avoid while using DermacinRx Lexitral PharmaPak?

Avoid exposing treated skin to heat, sunlight, or tanning beds.

Avoid taking a bath or shower within 30 minutes before or after you apply DermacinRx Lexitral PharmaPak to your skin. Also avoid vigorous exercise. Warm water or perspiration can increase the burning sensation caused by capsaicin.

Avoid getting this medicine in your eyes, nose, or mouth.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen).

What other drugs will affect DermacinRx Lexitral PharmaPak?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect DermacinRx Lexitral PharmaPak, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about DermacinRx Lexitral PharmaPak (capsaicin / diclofenac topical)

Patient resources

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.