Generic Name: dasatinib (da SAT in ib)
Brand Name: Sprycel
Dosage Forms: oral tablet (100 mg; 140 mg; 20 mg; 50 mg; 70 mg; 80 mg)
What is dasatinib?
Dasatinib is used in adults and children to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia (CML).
Dasatinib is also used to treat Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) in adults.
Dasatinib may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Some people using dasatinib have developed a rare but serious condition called pulmonary arterial hypertension (PAH). PAH occurs when blood pressure increases inside the arteries in your lungs. This makes it harder for your heart to pump blood through the lungs, which also weakens muscles in the heart. PAH may be irreversible if not promptly treated, and this condition can be fatal. Talk to your doctor about your specific risk of developing PAH.
Tell your doctor if you have ever had:
a weak immune system (caused by disease or by using certain medicines);
stomach or intestinal bleeding;
low levels of potassium or magnesium in your blood;
long QT syndrome (in you or a family member);
lung disease; or
Dasatinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using dasatinib, and for at least 30 days after your last dose. Tell your doctor right away if you become pregnant.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because dasatinib may harm the baby if a pregnancy does occur.
You should not breastfeed while taking dasatinib and for at least 2 weeks after your last dose.
How should I take dasatinib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take the medicine with or without food. Take the medicine at the same time each day.
Swallow the tablet whole and do not crush, chew, or break it.
Do not use a pill that has been accidentally broken. The medicine from a crushed or broken pill can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Wear rubber gloves while handling a broken tablet or capsule. Ask your doctor or pharmacist how to safely dispose of the broken pill. A pregnant woman should not handle a broken pill.
Dasatinib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
Do not change your dose or stop using dasatinib without your doctor's advice.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking dasatinib?
Grapefruit and grapefruit juice may interact with dasatinib and lead to unwanted side effects. Avoid the use of grapefruit products while taking dasatinib.
Avoid taking an antacid within 2 hours before or after you take dasatinib. Some antacids can make it harder for your body to absorb dasatinib.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Dasatinib side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor right away if you have any symptoms of pulmonary arterial hypertension (PAH), such as:
chest pain, feeling tired or short of breath (even with mild exertion);
swelling in your feet, lower legs, or midsection;
blue-colored lips and skin; and
a light-headed feeling, like you might pass out.
Also call your doctor at once if you have:
severe headaches, extreme tiredness, muscle or joint pain;
pain when you breathe, shortness of breath (especially when lying down);
swelling, rapid weight gain;
chest pain, pounding heartbeats or fluttering in your chest;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
low blood cell counts--fever, chills, tiredness, flu-like symptoms, mouth sores, skin sores, pale skin, cold hands and feet, feeling light-headed; or
signs of tumor cell breakdown--muscle cramps, nausea, vomiting, weakness, swelling, feeling short of breath, or seizure.
Dasatinib may affect growth in children. Tell your doctor if your child is not growing at a normal rate while using dasatinib.
Common side effects may include:
nausea, diarrhea, stomach pain;
headache, muscle pain, pain in your hands or feet;
skin rash; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Dasatinib dosing information
Usual Adult Dose for Leukemia:
Chronic Phase CML: 100 mg orally once a day
Accelerated Phase CML, Myeloid or Lymphoid Blast Phase CML, Ph+ ALL: 140 mg orally once a day
-Treatment should be continued until disease progression or unacceptable toxicity.
-The effect of discontinuing therapy after complete cytogenetic response is achieved has not been investigated.
-For the treatment of adults with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase
-For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib
-For the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy
Usual Pediatric Dose for Leukemia:
Body weight of 10 kg to less than 20 kg: 40 mg orally once a day
Body weight of 20 kg to less than 30 kg: 60 mg orally once a day
Body weight of 30 kg to less than 45 kg: 70 mg orally once a day
Body weight of at least 45 kg: 100 mg orally once a day
-The recommended starting dosage is based on body weight.
-The dose should be recalculated every 3 months or more often based on body weight changes.
-Patients with Ph+ ALL, start therapy on or before day 15 of induction chemotherapy, when diagnosis is confirmed and continue for 2 years.
-Tablet dosing is not recommended for patients weighing less than 10 kg.
-For the treatment of Ph+ CML in chronic phase
-For the treatment of newly diagnosed Ph+ ALL in combination with chemotherapy
What other drugs will affect dasatinib?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Dasatinib may increase your risk of severe or fatal bleeding, especially if you also use a blood thinner or any medication to prevent blood clots.
Many drugs can affect dasatinib, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2021 Cerner Multum, Inc. Version: 16.01.
More about dasatinib
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- 20 Reviews
- Drug class: BCR-ABL tyrosine kinase inhibitors
- FDA Alerts (1)
Other brands: Sprycel