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clindamycin (oral/injection)

Pronunciation

Generic Name: clindamycin (oral/injection) (klin da MYE sin)
Brand Name: Cleocin HCl, Cleocin Pediatric, Cleocin Phosphate, Cleocin Phosphate ADD-Vantage

What is clindamycin?

Clindamycin is an antibiotic that fights bacteria in the body.

Clindamycin is used to treat serious infections caused by bacteria.

Clindamycin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about clindamycin?

Clindamycin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. If you have diarrhea that is watery or bloody, stop using clindamycin and call your doctor.

What should I discuss with my healthcare provider before using clindamycin?

You should not use this medicine if you are allergic to clindamycin or lincomycin.

To make sure clindamycin is safe for you, tell your doctor if you have:

  • a history of colitis, Crohn's disease, or other intestinal disorder;

  • a history of eczema, or allergic skin reaction;

  • liver disease;

  • asthma, or a history of severe allergic reaction to aspirin;

  • if you also take erythromycin; or

  • if you are allergic to yellow food dye.

Clindamycin is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Clindamycin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Do not give a clindamycin injection to a child without medical advice. Injectable clindamycin contains an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not allow an older child to use this medicine without supervision of an adult.

How should I use clindamycin?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take the capsule with a full glass of water to keep it from irritating your throat.

Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Clindamycin is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

To make sure this medicine is not causing harmful effects, you may need frequent medical tests during treatment.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Clindamycin will not treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.

Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using clindamycin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using clindamycin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Clindamycin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Clindamycin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. If you have diarrhea that is watery or bloody, stop using clindamycin and call your doctor.

Call your doctor at once if you have:

  • any change in bowel habits;

  • little or no urination;

  • a metallic taste in your mouth;

  • signs of inflammation in your body--swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • nausea, vomiting, stomach pain;

  • mild skin rash; or

  • vaginal itching or discharge;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Clindamycin dosing information

Usual Adult Dose for Bacterial Infection:

Oral:
Serious infection: 150 to 300 mg orally every 6 hours
More severe infection: 300 to 450 mg orally every 6 hours

Parenteral:
Serious infection: 600 to 1,200 mg via IV infusion or IM injection per day, in 2 to 4 equally divided doses
Severe infection: 1,200 to 2,700 mg via IV infusion or IM injection per day, in 2 to 4 equally divided doses
More severe infection: Up to 4,800 mg via IV infusion per day

Comments:
-A single IM injection greater than 600 mg is not recommended
-A single 1 hour IV infusion greater than 1,200 mg is not recommended
-In the treatment of anaerobic infections, parenteral clindamycin should be used initially and then patients changed to oral therapy when clinically appropriate.
-Clindamycin should be reserved for penicillin-allergic patients or other patients for whom a penicillin is not appropriate.
-Combination therapy with additional antibiotics may be required according to standard treatment protocols. Treatment should be guided by culture and susceptibility studies.

Uses:
Serious infections caused by susceptible organisms:
-Staphylococci, streptococci, and pneumococci, including serious respiratory tract infections and skin and soft tissue infections
-Anaerobes, including serious respiratory tract infections, serious skin and soft tissue infections, septicemia, intraabdominal infections, and infections of the female pelvis and genital tract.
-Bone and joint infections including acute hematogenous osteomyelitis caused by Staphylococcus aureus and as adjunctive therapy in the surgical treatment of chronic bone and joint infections

Usual Pediatric Dose for Bacterial Infection:

Oral:
Body weight 10 kg or less:
Minimum recommended dose: 37.5 mg orally three times a day

Body weight 11 kg or more:
Serious infection: 8 to 12 mg/kg orally per day, in 3 to 4 equally divided doses
Severe infection: 13 to 16 mg/kg orally per day, in 3 to 4 equally divided doses
More severe infection: 17 to 25 mg/kg orally per day, in 3 to 4 equally divided doses

An alternate regimen:
Serious infection: 8 to 16 mg/kg orally per day, in 3 to 4 equally divided doses
More severe infection: 16 to 20 mg/kg orally per day, in 3 to 4 equally divided doses

Parenteral:
Up to 1 month of age: 15 to 20 mg/kg via IV infusion per day in 3 to 4 equally divided doses; the lower dose may be sufficient for small premature neonates.

1 month to 16 years:
Body weight dosing: 20 to 40 mg/kg via IV infusion or IM injection per day, in 3 to 4 equally divided doses. The higher doses would be used for more severe infections

Body surface area dosing:
Serious infection: 350 mg/m2 via IV infusion or IM injection per day
Severe infection: 450 mg/m2 via IV infusion or IM injection per day

17 years or older: Usual adult dose

Duration: At least 10 days for beta-hemolytic streptococcal infections

Comments:
-A single IM injection greater than 600 mg is not recommended
-A single 1 hour IV infusion greater than 1,200 mg is not recommended
-Parenteral therapy can be changed to oral therapy as clinically indicated.
-Clindamycin should be reserved for penicillin-allergic patients or other patients for whom a penicillin is not appropriate.
-Combination therapy with additional antibiotics may be required according to standard treatment protocols. Treatment should be guided by culture and susceptibility studies.

Uses:
Serious infections caused by susceptible organisms:
-Staphylococci, streptococci, and pneumococci, including serious respiratory tract infections and skin and soft tissue infections
-Anaerobes, including serious respiratory tract infections, serious skin and soft tissue infections, septicemia, intraabdominal infections, and infections of the female pelvis and genital tract.
-Bone and joint infections including acute hematogenous osteomyelitis caused by Staphylococcus aureus and as adjunctive therapy in the surgical treatment of chronic bone and joint infections

What other drugs will affect clindamycin?

Other drugs may interact with clindamycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about clindamycin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 10.01. Revision Date: 2016-04-18, 9:24:58 AM.

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