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Clindamycin: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on July 26, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Clindamycin is an antibiotic that is usually reserved for treating anaerobic infections or other serious infections caused by gram-positive bacteria in penicillin-allergic people. The risk of C. difficile-associated diarrhea may be higher with clindamycin compared with some other antibiotics.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with clindamycin may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with clindamycin. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with clindamycin include:

Clindamycin is a substrate of CYP3A4 and to a lesser extent, CYP3A5. It is a moderate inhibitor of CYP3A4. Drugs that inhibit CYP3A5 or CYP3A4 may cause increased blood concentrations of clindamycin. CYP3A4 or 3A5 inducers may decrease plasma concentrations of clindamycin.

Note that this list is not all-inclusive and includes only common medications that may interact with clindamycin. You should refer to the prescribing information for clindamycin for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use clindamycin only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: July 25, 2023.