Chlorpheniramine, dextromethorphan, and pseudoephedrine
Generic name: chlorpheniramine, dextromethorphan, and pseudoephedrine [ klor-feh-NEER-a-meen, dex-tro-meh-THOR-fan, and-soo-doe-eh-FEH-drin ]
Brand names: Kidkare Cough/Cold, Pediatric Cough & Cold Medicine, Rescon-DM, Triaminic Cold and Cough, Vicks Pediatric Formula 44M, ... show all 36 brands Triaminic Night Time, Rhinosyn-DM, Pediacare Nightrest, Pediacare Cough-Cold Chewable, Robitussin Pediatric Night Relief, Vicks 44M Pediatric, Creomulsion Cough/Cold/Allergy, Nyquil Child Cough and Cold, Creomulsion Pediatric, Pediacare Cough and Cold, Childrens Night Time, Children's NyQuil, Triaminic Softchew Cold and Cough, Tanafed-DM, C-Phed DM, T-Tanna-DM, M-End DM, Atuss-12 DM, Robitussin PM Cough and Cold, Dicel DM, Atuss DS, Pediatric Cough and Cold Medicine, Neutrahist PDX Drops, AccuHist PDX Drops, Triaminic Multi-Sympton, Allres DS, Triaminic-D Multi-Symptom Cold, Entre-S, Dicel DM Chewables, Mesehist DM, Esocor P
Dosage forms: oral liquid (1 mg-5 mg-15 mg/5 mL; 2 mg-10 mg-30 mg/5 mL; 2 mg-15 mg-30 mg/15 mL); oral tablet, chewable (1 mg-5 mg-15 mg)
Drug class: Upper respiratory combinations
What is chlorpheniramine, dextromethorphan, and pseudoephedrine?
Chlorpheniramine, dextromethorphan, and pseudoephedrine is a combination medicine used to treat cough, runny or stuffy nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.
Chlorpheniramine, dextromethorphan, and pseudoephedrine may also be used for purposes not listed in this medication guide.
Before taking this medicine
Do not use chlorpheniramine, dextromethorphan, and pseudoephedrine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Ask a doctor or pharmacist if this medicine is safe to use if you have:
asthma or COPD, cough with mucus;
a blockage in your digestive tract (stomach or intestines);
high blood pressure, heart disease;
liver or kidney disease;
enlarged prostate or urination problems;
overactive thyroid; or
pheochromocytoma (an adrenal gland tumor).
Liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
How should I take chlorpheniramine, dextromethorphan, and pseudoephedrine?
Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.
Always follow directions on the medicine label about giving cough or cold medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of cough or cold medicines in very young children.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
You must chew the chewable tablet before you swallow it.
Do not take for longer than 7 days in a row. Call your doctor if your symptoms do not improve after 7 days, or if you have a fever, rash, or headaches.
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since chlorpheniramine, dextromethorphan, and pseudoephedrine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking chlorpheniramine, dextromethorphan, and pseudoephedrine?
Drinking alcohol with this medicine can cause side effects.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Ask a doctor or pharmacist before using other cough, cold, allergy, or sleep medicines that may contain similar ingredients.
Avoid becoming overheated or dehydrated during exercise and in hot weather. This medicine can decrease sweating and you may be more prone to heat stroke.
chlorpheniramine, dextromethorphan, and pseudoephedrine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
severe anxiety, tremor, seizure (convulsions);
painful or difficult urination;
fast or pounding heartbeats; or
severe headache, pounding in your neck or ears.
Common side effects may include:
dry mouth, nose, or throat;
increased or decreased urination;
sleep problems (insomnia); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Chlorpheniramine, dextromethorphan, and pseudoephedrine dosing information
Usual Adult Dose for Cough and Nasal Congestion:
Oral liquid (2 mg chlorpheniramine/ 10 mg dextromethorphan / 30 mg pseudoephedrine per 5 mL): 10 mL orally every 4 hours
Maximum dose: 4 doses per 24 hours
Usual Pediatric Dose for Cough and Nasal Congestion:
Oral liquid (2 mg chlorpheniramine/ 10 mg dextromethorphan / 30 mg pseudoephedrine per 5 mL):
6 to 11 years: 5 to 10 mL orally every 4 to 6 hours
12 and older: 10 mL orally every 4 hours
Maximum dose: 4 doses per 24 hours
What other drugs will affect chlorpheniramine, dextromethorphan, and pseudoephedrine?
Avoid using this medicine with other drugs that cause drowsiness or slow your breathing (such as opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Ask a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed in this medication guide.
More about chlorpheniramine / dextromethorphan / pseudoephedrine
- Side effects
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (4)
- Drug class: upper respiratory combinations
- Other brands
- Kidcare Cough and Cold, Kidkare Cough/Cold, Maxichlor PSE DM, Pedia Relief Cough-Cold, ... +2 more
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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