Chlorpheniramine / Dextromethorphan / Pseudoephedrine Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 20, 2023.

Applies to chlorpheniramine / dextromethorphan / pseudoephedrine: oral liquid.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Dizziness.
• Feeling nervous and excitable.
• Not able to sleep.
• Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

For healthcare professionals

Applies to chlorpheniramine/dextromethorphan/pseudoephedrine: oral liquid, oral suspension extended release, oral tablet chewable.

Nervous system adverse events

• Frequency not reported: Excitability, drowsiness, nervousness, sleeplessness (combination product); headache, tremor, dizziness, insomnia (pseudoephedrine); sedation, impaired mental status (chlorpheniramine)^[Ref]

Cardiovascular

• Frequency not reported: Elevated blood pressure, tachycardia (pseudoephedrine)^[Ref]

Genitourinary

• Frequency not reported: Urinary retention (pseudoephedrine)^[Ref]

Ocular

• Frequency not reported: Elevated intraocular pressure (pseudoephedrine)^[Ref]

Other

• Frequency not reported: Fatigue (chlorpheniramine)^[Ref]

Further information

Chlorpheniramine/dextromethorphan/pseudoephedrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer