Chlorpheniramine / Dextromethorphan / Pseudoephedrine Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 20, 2023.
Applies to chlorpheniramine / dextromethorphan / pseudoephedrine: oral tablet chewable.
Important warnings
This medicine can cause some serious health issues
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
-
severe anxiety, tremor, seizure (convulsions);
-
painful or difficult urination;
-
fast or pounding heartbeats; or
-
severe headache, pounding in your neck or ears.
Common side effects may include:
-
dizziness, drowsiness;
-
blurred vision;
-
dry mouth, nose, or throat;
-
increased or decreased urination;
-
sleep problems (insomnia); or
-
nervousness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For healthcare professionals
Applies to chlorpheniramine/dextromethorphan/pseudoephedrine: oral liquid, oral suspension extended release, oral tablet chewable.
Nervous system adverse events
- Frequency not reported: Excitability, drowsiness, nervousness, sleeplessness (combination product); headache, tremor, dizziness, insomnia (pseudoephedrine); sedation, impaired mental status (chlorpheniramine)[Ref]
Cardiovascular
- Frequency not reported: Elevated blood pressure, tachycardia (pseudoephedrine)[Ref]
Genitourinary
- Frequency not reported: Urinary retention (pseudoephedrine)[Ref]
Ocular
- Frequency not reported: Elevated intraocular pressure (pseudoephedrine)[Ref]
Other
See also:
Promethazine VC with Codeine
Promethazine VC with Codeine is used for cough and nasal congestion
Mucinex D
Mucinex D (guaifenesin and pseudoephedrine) is used to treat nasal and sinus congestion, and to ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Robitussin Nighttime Cough DM
Robitussin Nighttime Cough DM is used for cough, cough and nasal congestion
Vicks Nyquil Cough
Vicks Nyquil Cough is used for cough, cough and nasal congestion
Dextromethorphan/guaifenesin/phenylephrine
Dextromethorphan/guaifenesin/phenylephrine systemic is used for cough and nasal congestion
Brompheniramine/dextromethorphan/pseudoephedrine
Brompheniramine/dextromethorphan/pseudoephedrine systemic is used for cough and nasal congestion
References
1. Sur DK, Plesa ML (2015) "Treatment of allergic rhinitis." Am Fam Physician, 92, p. 985-92
2. (2022) "Product Information. Kidkare Cough/Cold (chlorpheniramine/dextromethorphan/PSE)." Rugby Laboratories Inc
3. (2022) "Product Information. Rescon-DM (chlorpheniramine/dextromethorphan/PSE)." Capellon Pharmaceuticals
More about chlorpheniramine / dextromethorphan / pseudoephedrine
- Check interactions
- Compare alternatives
- Reviews (4)
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Patient resources
Other brands
Kidkare Cough/Cold, Maxichlor PSE DM, Pedia Relief Cough-Cold, Rescon-DM, ... +2 more
Related treatment guides
Further information
Chlorpheniramine/dextromethorphan/pseudoephedrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.