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Budesonide, formoterol, and glycopyrrolate

Generic Name: budesonide, formoterol, and glycopyrrolate (bue DES oh nide, for MOE te rol, and GLYE koe PIR oh late)
Brand Name: Breztri Aerosphere
Dosage Forms: inhalation aerosol (160 mcg-4.8 mcg-9 mcg/inh)

Medically reviewed by Drugs.com on Sep 14, 2020. Written by Cerner Multum.

What is budesonide, formoterol, and glycopyrrolate?

Budesonide is a steroid. Formoterol is a long-acting bronchodilator. Glycopyrrolate is an anticholinergic.

Budesonide, formoterol, and glycopyrrolate is a combination medicine used in adults to help control the symptoms of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

budesonide, formoterol, and glycopyrrolate is not for use in treating asthma or a bronchospasm attack.

Budesonide, formoterol, and glycopyrrolate may also be used for purposes not listed in this medication guide.

Important Information

Budesonide, formoterol, and glycopyrrolate is not a rescue medicine for bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Before taking this medicine

You should not use this medicine if you are allergic to budesonide, formoterol, or glycopyrrolate (this includes Pulmicort, Rhinocort, Perforomist, Bevespi, Dulera, and others).

Budesonide can weaken your immune system. Tell your doctor about any illness or infection you've had within the past several weeks.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

This medicine is not approved for use by anyone younger than 18 years old.

How should I take budesonide, formoterol, and glycopyrrolate?

Follow all directions on your prescription label and read all medication guides. Use the medicine exactly as directed. Using too much of this medicine can cause life-threatening side effects.

Budesonide, formoterol, and glycopyrrolate is not a rescue medicine for bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Rinse your mouth with water after each use of your inhaler.

Your medication needs may change if you have surgery, are ill, are under stress, or have worsening COPD symptoms. Do not change your medication dose or stop using this medicine without your doctor's advice.

Store at room temperature away from sunlight, open flame, or high heat. The canister may explode if it gets too hot. Do not puncture or burn an empty inhaler canister.

Do not open the foil pouch until you are ready to use the medicine.

Throw the canister away when the inhalations counter shows a 0, or 3 months after you first removed the 120-inhalation canister from its foil pouch (3 weeks after if you are using the 28-inhalation canister), whichever comes first.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include chest pain, fast heartbeats, and feeling shaky or short of breath.

What should I avoid while taking budesonide, formoterol, and glycopyrrolate?

If this medication gets in your eyes, rinse with water and call your doctor if you have severe eye redness.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using a steroid such as budesonide.

Ask your doctor before using a second inhaled bronchodilator that contains formoterol or a similar medicine (such as arformoterol, formoterol, indacaterol, olodaterol, salmeterol, or vilanterol).

budesonide, formoterol, and glycopyrrolate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsened breathing problems;

  • wheezing, choking, or other breathing problems after using this medication;

  • tremors, nervousness, chest pain, fast or pounding heartbeats;

  • sores or white patches in your mouth and throat, pain when swallowing;

  • flu symptoms, body aches, unusual tiredness;

  • painful or burning when you urinate, little or no urination;

  • blurred vision, tunnel vision, eye pain or redness, or seeing halos around lights;

  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

  • signs of a lung infection--fever, chills, cough with mucus, chest pain, feeling short of breath; or

  • signs of a hormonal disorder--tiredness or weakness, feeling light-headed, nausea, vomiting.

Common side effects may include:

  • throat pain or irritation;

  • white patches in your mouth or throat;

  • headache, joint pain, muscle spasms;

  • pounding heartbeats, feeling anxious;

  • high blood sugar levels;

  • painful or difficult urination;

  • nausea, diarrhea;

  • cough, hoarse voice;

  • flu symptoms; or

  • cold symptoms such as stuffy or runny nose, sneezing, sinus pain, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Budesonide, formoterol, and glycopyrrolate dosing information

Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:

Budesonide 160 mcg/ glycopyrrolate 8 mcg/ formoterol fumarate 4.8 mcg inhalation: 2 oral inhalations (budesonide 320 mcg/ glycopyrrolate 18 mcg/ formoterol fumarate 9.6 mcg) twice daily (morning and evening)
Maximum dose: 2 inhalations twice a day

What other drugs will affect budesonide, formoterol, and glycopyrrolate?

Tell your doctor about all your current medicines. Do not use any of the following medicines without first asking your doctor:

This list is not complete and many other drugs may affect budesonide, formoterol, and glycopyrrolate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.