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Budesonide / Formoterol / Glycopyrrolate Dosage

Medically reviewed by Drugs.com. Last updated on Sep 14, 2020.

Applies to the following strengths: 160 mcg-4.8 mcg-9 mcg/inh

Usual Adult Dose for Chronic Obstructive Pulmonary Disease - Maintenance

Budesonide 160 mcg/ glycopyrrolate 8 mcg/ formoterol fumarate 4.8 mcg inhalation: 2 oral inhalations (budesonide 320 mcg/ glycopyrrolate 18 mcg/ formoterol fumarate 9.6 mcg) twice daily (morning and evening)
Maximum dose: 2 inhalations twice a day

Renal Dose Adjustments

Severe renal impairment (CrCl 30 mL/min/1.72 m2 or lower): Use only if expected benefit outweighs potential risk.
-Pharmacokinetic studies have not been performed in renally impaired patients.

Liver Dose Adjustments

Severe hepatic impairment: Monitor closely
-Pharmacokinetic studies have not been performed in hepatically impaired patients.
-Budesonide and formoterol fumarate are primarily hepatically metabolized, so liver impairment may lead to drug accumulation in the plasma.

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to any of the ingredients

Safety and efficacy have not been established in patients younger than 18 years.
This drug is not recommended for use in children.

Consult WARNINGS section for additional precautions.

Dialysis

Use only if expected benefit outweighs potential risk.
-Pharmacokinetic studies have not been performed in renally impaired patients.

Other Comments

Administration advice:
-After inhalation, rinse mouth with water without swallowing.
-Prime inhaler before first use by releasing 4 sprays into the air away from face.
-Prime inhaler by releasing 2 sprays if not used for more than 7 days, if dropped, or after weekly cleaning.
-Discard when dose counter shows zero.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.