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Aspirin and oxycodone

Generic name: aspirin and oxycodone (AS pir in and ox i KOE done)
Brand name: Percodan, Percodan-Demi, Roxiprin, Endodan
Dosage forms: oral tablet (325 mg-4.8355 mg)
Drug class: Narcotic analgesic combinations

Medically reviewed by Drugs.com on May 10, 2021. Written by Cerner Multum.

What is aspirin and oxycodone?

Aspirin and oxycodone is a combination opioid medicine that is used to relieve moderate to severe pain.

Aspirin and oxycodone may also be used for purposes not listed in this medication guide.

Warnings

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects may occur if you use also use alcohol or other drugs that cause drowsiness or slow breathing.

Before taking this medicine

You should not take aspirin and oxycodone if you are allergic to aspirin or oxycodone, or if you have:

Do not give this medicine to a child. Using this medicine in a child or teenager with flu symptoms or chickenpox can cause a serious or fatal condition called Reye's syndrome.

Tell your doctor if you have ever had:

If you use this medicine during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks. You should not use aspirin and oxycodone after 30 weeks of pregnancy.

Ask a doctor if it is safe to breastfeed. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

How should I take aspirin and oxycodone?

Follow the directions on your prescription label and read all medication guides. Never use aspirin and oxycodone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Aspirin and oxycodone may be taken with food if it upsets your stomach.

Tell your doctor if you have a planned surgery.

Do not stop using aspirin and oxycodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Since aspirin and oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opioid overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

What should I avoid while taking aspirin and oxycodone?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how aspirin and oxycodone will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to aspirin (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Aspirin and oxycodone side effects

Get emergency medical help if you have signs of an allergic reaction: hives, rash; fever, difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • weak or shallow breathing, breathing that stops during sleep;

  • severe constipation;

  • confusion, unusual thoughts or behavior, feeling like you might pass out;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or

  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, feeling weak or tired.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects may include:

  • stomach pain, nausea, vomiting, constipation;

  • headache, dizziness, drowsiness, tiredness;

  • rash; or

  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Aspirin and oxycodone dosing information

Usual Adult Dose for Pain:

Initial dose: 1 tablet (oxycodone 5 mg/aspirin 325 mg) orally every 6 hours as needed for pain
-Adjust dose to a dose that provides adequate analgesia while minimizing adverse reactions
Maximum dose: 12 tablets in 24 hours
Maximum Aspirin dose: 4 g in 24 hours

Comments:
-Because of the risks of addiction, abuse and misuse, the lowest effective dose for the shortest duration consistent with individual patient treatment goals should be used.
-Monitor patients closely for respiratory depression within the first 24 to 72 hours of initiating therapy and following any increase in dose.

Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

What other drugs will affect aspirin and oxycodone?

You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines, especially an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.

Opioid medicine can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may affect aspirin and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Does Aspirin/oxycodone interact with my other drugs?

Enter other medications to view a detailed report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.