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aspirin and oxycodone

Generic Name: aspirin and oxycodone (AS pir in and ox i KOE done)
Brand Name: Percodan, Percodan-Demi, Roxiprin, Endodan

What is aspirin and oxycodone?

Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation. Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Aspirin and oxycodone is a combination medicine used to relieve moderate to severe pain.

Aspirin and oxycodone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about aspirin and oxycodone?

Aspirin and oxycodone can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

What should I discuss with my healthcare provider before taking aspirin and oxycodone?

You should not take this medicine if you are allergic to aspirin or oxycodone (OxyContin), or if you have:

  • a bleeding or blood clotting disorder such as hemophilia;

  • ulcer or obstruction in the stomach;

  • severe asthma or breathing problems;

  • an allergy to any NSAID (nonsteroidal anti-inflammatory drug); or

  • if you are taking a blood thinner such as warfarin (Coumadin, Jantoven).

Do not use aspirin and oxycodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Do not give this medication to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.

To make sure aspirin and oxycodone is safe for you, tell your doctor if you have:

  • stomach or intestinal disorder, history of stomach ulcer or bleeding;

  • any type of breathing problem or lung disease;

  • urination problems;

  • liver or kidney disease;

  • a history of head injury, brain tumor, or seizures;

  • a history of drug abuse, alcohol addiction, or mental illness;

  • problems with your gallbladder, pancreas, thyroid, or adrenal gland; or

  • if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).

Do not use this medicine if you are pregnant. Use effective birth control to prevent pregnancy while taking aspirin and oxycodone.

  • If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

  • Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Aspirin and oxycodone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using aspirin and oxycodone.

How should I take aspirin and oxycodone?

Follow all directions on your prescription label. Oxycodone can slow or stop your breathing. Never use aspirin and oxycodone in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Oxycodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away aspirin and oxycodone is against the law.

Aspirin and oxycodone may be taken with food if it upsets your stomach.

If you need surgery, tell the surgeon ahead of time that you are using aspirin and oxycodone. You may need to stop using the medicine for a short time.

Do not stop using aspirin and oxycodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light. Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Do not keep unused aspirin and oxycodone that is no longer needed. Ask your pharmacist where to locate a community drug take-back disposal program. If there is no take-back program, flush any unused medicine down the toilet.

What happens if I miss a dose?

Since aspirin and oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A aspirin and oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

What should I avoid while taking aspirin and oxycodone?

Do not drink alcohol. Dangerous side effects or death could occur.

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how aspirin and oxycodone will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Ask your doctor before using aspirin and oxycodone if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist before using any other over-the-counter cold, allergy, or pain medicine. Aspirin is contained in many combination medicines. Taking certain products together can cause you to get too much aspirin. Check the label to see if a medicine contains aspirin.

Aspirin and oxycodone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medicines, oxycodone can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • severe stomach pain or constipation, vomiting;

  • easy bruising, unusual bleeding, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • weak or shallow breathing, fast or slow heartbeat;

  • confusion, hallucinations, unusual thoughts or behavior, feeling like you might pass out;

  • infertility, missed menstrual periods;

  • impotence, sexual problems, loss of interest in sex;

  • decreased hearing or ringing in the ears;

  • seizure (convulsions); or

  • low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Aspirin and oxycodone is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

Common side effects may include:

  • headache, dizziness, drowsiness;

  • constipation, heartburn, upset stomach, bloating, gas, diarrhea; or

  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Aspirin and oxycodone dosing information

Usual Adult Dose for Pain:

Initial dose: 1 tablet (oxycodone 5 mg/aspirin 325 mg) orally every 6 hours as needed for pain
-Adjust dose to a dose that provides adequate analgesia while minimizing adverse reactions
Maximum dose: 12 tablets in 24 hours
Maximum Aspirin dose: 4 g in 24 hours

Comments:
-Because of the risks of addiction, abuse and misuse, the lowest effective dose for the shortest duration consistent with individual patient treatment goals should be used.
-Monitor patients closely for respiratory depression within the first 24 to 72 hours of initiating therapy and following any increase in dose.

Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

What other drugs will affect aspirin and oxycodone?

Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

  • other narcotic medications--opioid pain medicine or prescription cough medicine;

  • drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or

  • drugs that affect serotonin levels in your body--medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

This list is not complete. Other drugs may interact with aspirin and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

See also: Side effects (in more detail)

Where can I get more information?

  • Your pharmacist can provide more information about aspirin and oxycodone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 9.07.

Last reviewed: May 03, 2017
Date modified: August 01, 2017

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