Amcinonide (Monograph)
Drug class: Corticosteroids
ATC class: D07AC11
VA class: DE200
Chemical name: (11β,16α)-21-(acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-pregna-1,4-diene-3,20-dione
CAS number: 51022-69-6
Introduction
Amcinonide is a synthetic fluorinated corticosteroid.
Uses for Amcinonide
Amcinonide shares the actions of the other topical corticosteroids and is used for the relief of the inflammatory manifestations of corticosteroid-responsive dermatoses. Based on clinical studies in patients with various dermatoses and on vasoconstrictor assay, the anti-inflammatory activity of 0.1% amcinonide cream is similar to that of 0.1% betamethasone valerate cream, 0.1% triamcinolone acetonide cream, or 0.025% fluocinolone acetonide cream.
Amcinonide Dosage and Administration
Topical amcinonide cream or ointment are applied sparingly in a thin film to the affected area 2 or 3 times daily. The cream is rubbed in gently and thoroughly. Amcinonide lotion, which may be particularly useful for use on the scalp and hairy areas of the trunk and extremities, is applied and rubbed thoroughly into the affected area twice daily. Following application of the lotion, the affected area should be protected (i.e., from washing, clothing, or rubbing) until the lotion has dried. Occlusive dressings may be used for severe or resistant dermatoses.
Chemistry and Stability
Chemistry
Amcinonide is a synthetic fluorinated corticosteroid. Amcinonide occurs as a white solid and is insoluble in water.
Stability
Amcinonide cream should be stored in well-closed containers at a temperature less than 40°C, preferably between 15–30°C; freezing should be avoided. Amcinonide lotion and ointment should be stored at 15–30°C; freezing of the lotion should be avoided.
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes |
Dosage Forms |
Strengths |
Brand Names |
Manufacturer |
---|---|---|---|---|
Topical |
Cream |
0.1%* |
Cyclocort (with benzyl alcohol 2% and Aquatain hydrophilic base) |
Astellas |
Lotion |
0.1%* |
Cyclocort (with benzyl alcohol 1% w/w and Aquatain hydrophilic base) |
Astellas |
|
Ointment |
0.1% |
Cyclocort (with benzyl alcohol and propylene glycol) |
Astellas |
AHFS DI Essentials™. © Copyright 2025, Selected Revisions January 29, 2018. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.
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