How is Zulresso administered for the treatment of Postpartum Depression?

Medically reviewed by Judith Stewart, BPharm. Last updated on March 6, 2025.

Official Answer by Drugs.com

How long does the treatment take? Can I receive the injection at home?

Update: As of January 1, 2025, Zulresso (brexanolone) will no longer be commercially available in the U.S.

Zulresso is an injection that is given as a continuous intravenous (IV) infusion into your vein over a period of 60 hours (2.5 days).

Zulresso (brexanolone) is the first drug to be FDA approved specifically for postpartum depression, a major depressive episode that occurs following childbirth. Severe cases of postpartum depression can be life life-threatening.

Zulresso can cause serious side effects including excessive sedation (sleepiness) or sudden loss of consciousness. Before you receive Zulresso, you must first be enrolled in a program called the Zulresso REMS, a restricted program that requires that the treatment is provided under medical supervision in a certified health care facility.

You will need to be hospitalized for the entire duration of treatment, so you cannot receive the injection at home. During this period, you will be monitored for excessive sedation every two hours during the normal time you are awake, and you will have continuous pulse oximetry monitoring to monitor oxygen levels in your blood. You will also need to be accompanied during all interactions with your child(ren). Once the treatment is complete, you should not drive, operate machinery, or do other dangerous activities until feelings of sleepiness have completely gone away.

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How is Zulresso administered for the treatment of Postpartum Depression?

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