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Is it okay to take Vyvanse while on birth control?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on May 26, 2025.

Official Answer by Drugs.com

Key Points

Can Vyvanse increase blood pressure if taken with birth control?

Tell your doctor you take birth control before starting Vyvanse treatment. Vyvanse can cause an increase in blood pressure and heart (pulse) rate. Estrogens and progestins found in birth control may also cause or worsen high blood pressure. When taken together, Vyvanse and birth control could increase the risk for high blood pressure, a heart attack, stroke or other heart problem due to an additive effect on high blood pressure.

Patients taking high doses or prolonged use of estrogens and progestins, who are over the age of 35, or who are smokers may have an even higher risk of heart problems if Vyvanse is combined with birth control.

In patients requiring contraception, alternative methods without estrogen or progestin should be considered for those who have high blood pressure, are over the age of 35, and smoke.

Are there dangerous drug interactions with Vyvanse?

There are many important drug interactions with Vyvanse, some of which can be serious or fatal. You can review these interactions here.

Keep a list of the medicines you take and show them to your doctor and pharmacist before you start a new medicine. This includes over-the-counter (OTC) medicines, vitamins, herbs or other dietary supplements. Do not start any new medicine while taking Vyvanse without talking to your doctor first.

Your doctor or pharmacist should check to see if you are taking any drugs that can interact with Vyvanse when you start treatment, and they should also review for drug interactions each time you start (or even stop) a medicine.

One important interaction is between Vyvanse and a class of drugs known as MAO inhibitors. Do not use Vyvanse if you have taken an MAO inhibitor in the past 14 days due to the chance for a dangerous, possibly fatal drug interaction.

CYP enzymes are a family of enzymes in our bodies that are primarily found in the liver and intestines. CYP enzymes have many roles, including helping to clear drugs and toxins from the body.

There are other drug interactions with Vyvanse. Tell your doctor and pharmacist about all of the medicines that you take, including prescription and over-the-counter (OTC) medicines, vitamins, and herbal supplements.

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Bottom Line

This is not all the information you need to know about Vyvanse for safe and effective use. Review the full product information here, and discuss this information with your doctor or other health care provider.

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