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How is Vyepti different from Aimovig?

Medically reviewed by Melisa Puckey, BPharm. Last updated on March 11, 2025.

Official Answer by Drugs.com

How well does Vyepti work compared to Aimovig?

These figures are from individual drug clinical trials and not from comparison trials. In the individual clinical trials the drug is compared to a placebo.

Decrease in chronic migraine days:

Patients who had Chronic migraines reduced by half

Decrease in days of episodic migraine headache days

Patients who had episodic migraines reduced by half

How do the side effects of Aimovig and Vyepti compare?

Table of Aimovig and Vyepti

Aimovig (erenumab-aooe) Vyepti (eptinezumab-jjmr)
Indications for use Preventive treatment of migraine in adults Preventive treatment of migraine in adults
FDA approval date May 17, 2018 February 21, 2020
Form Subcutaneous injection:
Single-dose prefilled SureClick® autoinjector Single-dose prefilled syringe
Intravenous infusion
Dose 70mg or 140mg injection once a month 100mg or 300mg infusion every 3 months
Half life 28 days 27 days
Effectiveness Preventing Chronic Migraine:(Decrease in days monthly migraine headache days compared to placebo -2.5 days Aimovig 70mg
-2.5 days
Aimovig 140mg
-2 days Vyepti 100mg:
-2.6 days Vyepti 300mg
Effectiveness Preventing Chronic Migraine: (Percentage of patients who had their migraines reduced by half or greater compared to placebo) 16.4% Aimovig 70mg
17.7% Aimovig 140mg
18.3% Vyepti 100mg
22.1% Vyepti 300mg
Effectiveness for Episodic Migraine: Decrease in days of episodic migraine headache days per month -1.0 days Aimovig 70mg -0.7 days Vyepti 100mg
-1.1 days Vyepti 300mg
Effectiveness Preventing Episodic Migraine: (Percentage of patients who had their episodic migraines reduced by half or greater compared to placebo) 10.2% Aimovig 70mg 18.3% Vyepti 100mg
22.1% Vyepti 300mg
Side effects
(if + then drug has more side effects than placebo, if - then drug has less side effects than placebo)
Nasopharyngitis:
Aimovig 70mg -0.1%
Aimovig 140mg 1%
Upper respiratory tract infection:
Aimovig 70mg 1.1%
Aimovig 140mg -0.9%%
Sinusitis:
Aimovig 70mg 0%
Aimovig 140mg 1.2%
Fatigue:
Aimovig 70mg -0.6%
Aimovig 140mg -0.3%
Nausea:
Aimovig 70mg 0.3%
Aimovig 140mg 0%
Urinary tract infection:
Aimovig 70mg -0.6%
Aimovig 140mg 0%
Constipation:
Aimovig 70mg 0.3%
Aimovig 140mg 2.1%
Nasopharyngitis:
Vyepti 100mg -0.7%,
Vyepti 300mg 3.4%
Upper respiratory tract infection: Vyepti 100mg -1.3%,
Vyepti 300mg -0.1%.
Sinusitis:
Vyepti 100mg -2.1%,
Vyepti 300mg -1.5%
Fatigue:
Vyepti 100mg 0.3%,
Vyepti 300mg -0.2%
Nausea:
Vyepti 100mg -0.2%
Vyepti 300mg 1.5%
Urinary tract infection:
Vyepti 100mg 0.6%
Vyepti 300mg 1.8
Allergen: latex Aimovig prefilled autoinjector contains latex in needle shield within the white or orange cap.
Aimovig prefilled syringe contains latex in gray needle cap
Not present

Bottom line:

Related questions

References

Read next

How long does Aimovig last in your system?

It takes approximately 154 days (22 weeks, or over 5 months) for Aimovig to be eliminated out of your system. Aimovig is a prescription medicine injected monthly for the preventive treatment of migraine in adults. Continue reading

What is the mechanism of action of Aimovig?

Aimovig (erenumab-aooe) works by blocking the calcitonin gene-related peptide (CGRP) receptor binding site and function. This helps to prevent the development of a migraine headache and associated pain. CGRP is a protein thought to cause blood vessels to dilate and lead to inflammation and migraine headache pain. Continue reading

How long can Aimovig be out of the fridge?

Once you remove Aimovig (erenumab-aooe) from the refrigerator, you must use it within 7 days. Do not put Aimovig back in the refrigerator after it has reached room temperature Continue reading

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