Is Nurtec a Triptan? How it differs from other migraine drugs?
Nurtec ODT (rimegepant) is not a triptan. It is a CGRP receptor antagonist, offering a new approach for both acute and preventive migraine management.
Why the Confusion?
Many confuse Nurtec with triptans because both drugs treat migraines. Triptans, such as sumatriptan, have been widely used for decades and are often the first medications recommended for acute migraine attacks. Since Nurtec is approved for similar uses, patients and providers sometimes mistakenly think the drugs are alike.
How Nurtec Works
Nurtec belongs to a class called CGRP (calcitonin gene-related peptide) receptor antagonists, also known as "gepants.” CGRP is a protein involved in migraine pain and neurogenic inflammation. By blocking the effects of CGRP, Nurtec helps stop migraines from developing and reduces the frequency of attacks when taken regularly for prevention.
Nurtec vs. Triptans
Nurtec appears to have less cardiovascular-related side effects compared to triptans, making it an option for those with cardiovascular concerns. However, worsening of or new high blood pressure can occur. Most triptans work by activating serotonin receptors, which can tighten blood vessels, so they are avoided in those with a history of stroke or heart disease.
| Feature | Nurtec (Rimegepant) | Triptans (e.g., Sumatriptan) |
|---|---|---|
| Drug class | CGRP antagonist | Serotonin (5-HT1B/1D) agonist |
| Use | Acute + preventive | Acute only |
| Generic available | No | Yes (most forms) |
| CV safety | Generally safer | Caution for heart patients |
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Who Should Consider Nurtec?
Nurtec may be a good option for:
- People with heart or vascular conditions who should avoid triptans.
- Patients who do not respond well to triptans or experience side effects.
- Those wanting one medication for both acute treatment and prevention of migraines.
Discuss your full medical history and goals with your healthcare provider so they can help you determine the best treatment options for you.
This is not all the information you need to know about Nurtec ODT for safe and effective use and does not take the place of your doctor’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.
References
- Ailani, J., et. al. 2021. The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice. In: Headache. DOI: https://doi.org/10.1111/head.14153
- Favoni, V., Giani, L., Al-Hassany, L., Asioli, G. M., Butera, C., de Boer, I., Guglielmetti, M., Koniari, C., Mavridis, T., Vaikjärv, M., Verhagen, I., Verzina, A., Zick, B., Martelletti, P., Sacco, S., & European Headache Federation School of Advanced Studies (EHF-SAS) (2019). CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?. The journal of headache and pain, 20(1), 27. https://doi.org/10.1186/s10194-019-0979-y
- Lew C, Punnapuzha S. Migraine Medications. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Accessed on August 31, 2025 at https://www.ncbi.nlm.nih.gov/books/NBK553159/
- Nurtec ODT [package insert]. Updated August 11, 2025. Pfizer Laboratories Div Pfizer Inc. Accessed on August 31, 2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9ef08e09-1098-35cc-e053-2a95a90a3e1d
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