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How long do antibiotics take to work?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on June 12, 2025.

Official Answer by Drugs.com

Antibiotics are life-saving medicines used to treat bacterial infections, but many people wonder how quickly they can expect to feel better after starting a course. The answer depends on several factors, including the type of antibiotic, the infection or condition being treated, and individual health differences.

How Quickly Do Antibiotics Begin Working?

Antibiotics start to act against bacteria soon after the first dose enters your system. For example, medications like oral amoxicillin reach their peak concentration in the body within one to two hours after ingestion. However, while the medicine is working at the microscopic level, symptom relief is not immediate.

When Will You Start to Feel Better?

Most people begin to notice improvement in their symptoms within 24 to 72 hours (one to three days) after starting antibiotic treatment. This time frame can vary:

Even though antibiotics start fighting bacteria quickly, your immune system also needs time to recover from the infection and reduce inflammation, which is often responsible for many symptoms. This explains why you might not feel immediate relief even though the medication is active in your body. People with a weak immune system might take longer to fight off an infection, even with antibiotic treatment.

Does the Type of Antibiotic Matter?

Yes, different antibiotics have different onset times:

Why Is It Important to Finish the Course?

It’s important to complete the entire prescribed course of antibiotics, even if you feel better before finishing the medication. Stopping early can allow some bacteria to survive, potentially leading to a return of the infection and increasing the risk of antibiotic resistance.

Key Takeaways

References
  1. American Academy of Dermatology Association. How long can I take an antibiotic to treat my acne? Accessed on June 12, 2025 at https://www.aad.org/public/diseases/acne/derm-treat/antibiotics
  2. Amoxicillin [package insert]. Updated 2024. Micro Labs Limited. Accessed on June 12, 2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=42f935ca-45ba-4b3e-8b40-9b2d4eb56281
  3. Azithromycin [package insert]. Updated 2024. Taro Pharmaceuticals U.S.A., Inc. Accessed on June 12, 2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=071e71b8-bb53-4075-9bda-2ec48affa018
  4. HealthyChildren.org. (2022). Antibiotics for Children: 10 common questions answered. American Academy of Pediatrics. Accessed on June 12, 2025 at https://www.healthychildren.org/English/safety-prevention/at-home/medication-safety/Pages/Antibiotic-Prescriptions-for-Children.aspx
  5. National Health Service. 2022. Antibiotics. Accessed on June 12, 2025 at https://www.nhs.uk/conditions/antibiotics/
  6. National Health Service. 2022. Doxycycline. Accessed on June 12, 2025 at https://www.nhs.uk/medicines/doxycycline/about-doxycycline/
  7. National  Health Service. 2023. Osteomyelitis. Accessed on June 12, 2025 at https://www.nhs.uk/conditions/osteomyelitis/
  8. Spellberg, B., & Rice, L. B. (2019). Duration of Antibiotic Therapy: Shorter Is Better. Annals of internal medicine, 171(3), 210–211. https://doi.org/10.7326/M19-1509

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