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How is Kyprolis (carfilzomib) administered?

Medically reviewed by Melisa Puckey, BPharm. Last updated on March 12, 2024.

How is Kyprolis (carfilzomib) given?

Official answer


Kyprolis (carfilzomib) for injection is given as an intravenous (IV) infusion, which involves delivering the medication directly into a vein via a needle. A Kyprolis infusion is usually administered in a clinic, hospital or doctor’s office.

Kyprolis is used to treat relapsed or refractory multiple myeloma and may be given on its own or in combination with other medicines including dexamethasone Daratumumab (Darzalex), Daratumumab and hyaluronidase-fihj (Darzalex Faspro), Lenalidomide (Revlimid), or Isatuximab (Sarclisa).

How long does it take to receive a Kyprolis infusion?

The time it takes to infuse Kyprolis varies from 10 to 30 minutes, depending on the dose of Kyyprolis, the combination of medicines required and whether it is given once a week or twice a week.

How many Kyprolis infusion per week will I have?

Kyprolis is given once or twice a week depending on dose and medication combinations

How long is a treatment cycle for Kyprolis?

A standard Kyprolis treatment cycle involves receiving infusions once or twice a week for 3 weeks, then a week without treatment, this is one 28 day cycle. The treatment cycle can be repeated until disease progression or unacceptable toxicity.

Kyprolis Regime, Dose and Infusion time

Regimen Dosage Infusion Time
Kyprolis and Dexamethasone (Kd) or
Kyprolis, Daratumumab and Dexamethasone (DKd) or
Kyprolis, Daratumumab and hyaluronidase-fihj and Dexamethasone (DKd)
20/70 mg/m2 once weekly 30 minutes
Kyprolis and Dexamethasone (Kd) or
Kyprolis, Daratumumab and Dexamethasone (DKd) or
Kyprolis, Daratumumab and hyaluronidase-fihj and Dexamethasone (DKd) or
Kyprolis, Isatuximab and Dexamethasone (Isa-Kd) or
Kyprolis Monotherapy
20/56 mg/m2 twice weekly 30 minutes
Kyprolis, Lenalidomide and Dexamethasone (KRd) or
Kyprolis Monotherapy
20/27 mg/m2 twice weekly 10 minutes

Related Questions

What precautions need to be taken when Kyprolis is being administered?

Standard administration precautions include:

  • Ensuring the patient is adequately hydrated, especially before the first dose of Kyprolis is given and also in patient’s at high risk of tumor lysis syndrome (TLS) or kidney toxicity.
  • Monitoring of serum potassium levels, which should be done regularly during treatment.
  • Pre-treatment with dexamethasone to reduce the incidence of and severity of infusion-related adverse reactions.
  • Administering medication to prevent blood clots in patients receiving Kyprolis and dexamethasone or with lenalidomide plus dexamethasone.
  • Administering antiviral medications to prevent herpes reactivation in those patients at risk.
  • Administering Kyprolis after hemodialysis in those patients who receive it.
  • Kyprolis Package Insert FDA . [Accessed March 12, 2024].
  • Kyprolis. About Kyprolis. [March 12, 2024]. Available online at:

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