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How do you use Kevzara (sarilumab) for the treatment of rheumatoid arthritis?

Medically reviewed by Last updated on Sep 23, 2019.

Official Answer


Kevzara (sarilumab) is an interleukin-6 receptor (IL-6R) antibody for the treatment of adults with rheumatoid arthritis. It is given as a subcutaneous injection, which can be self-administered.

Kevzara (sarilumab) used to treat moderate-to-severe rheumatoid arthritis in patients who failed, or cannot tolerate at least one other disease modifying antirheumatic drug (DMARD). Kevzara may be used alone as monotherapy, or in combination with methotrexate or other conventional DMARDs.

The recommended dosage of Kevzara is 200 mg once every two weeks given as a subcutaneous injection, which can be self-administered. The dosage can be reduced from 200 mg to 150 mg once every two weeks, as needed, to help manage certain laboratory abnormalities (neutropenia, thrombocytopenia, and liver enzyme elevations).

Kevzara is available as a single-use pre-filled syringe or single-use pre-filled pen. The injection can be self-injected into the front of the thigh or abdomen, but not the area 2 inches around the navel. If somebody else administers the injection, it can also be given in the upper arm.

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