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How long does it take for Kevzara to work?

Medically reviewed by Carmen Fookes, BPharm. Last updated on April 15, 2020.

Official Answer

  • Kevzara usually takes between two and 12 weeks to start working.
  • Kevzara blocks the actions of interleukin-6, a type of protein that significantly contributes to the symptoms of rheumatoid arthritis.
  • It reduces symptoms of Rheumatoid Arthritis such as painful, tender and swollen joints; anemia, osteoporosis, and fatigue.

Kevzara (sarilumab) is used to treat moderate to severe rheumatoid arthritis (RA) in adults.

It belongs to a family of medicines called interleukin-6 (IL-6) inhibitors and is a type of biologic.

Kevazara works by blocking the effects of a protein called interleukin-6. IL-6 is a type of inflammatory cytokine and it is involved in several different processes within the body, including inducing the production of C-reactive protein (CRP) by the liver.

IL-6 contributes significantly to the symptoms of rheumatoid arthritis. It is found in abundance in the synovial fluid and serum of people with RA and levels of IL-6 are higher during periods of increased disease activity and joint destruction. It also contributes to other symptoms of RA, such as anemia, osteoporosis, and fatigue.

Kevzara is usually given once every two weeks as a subcutaneous (under the skin) injection.

Following a single injection of Kevzara, a rapid reduction in CRP levels was observed within two weeks in most people, although it may take up to 12 weeks (three months) for Kevzara to work in some people.

Even if Kevzara doesn’t seem to be working for you at first, you should continue administering it every two weeks until 12 weeks have passed.

Kevzara reduced symptoms such as painful, tender and swollen joints. It has also been shown to slow the progression of RA, protecting the joints from further damage.

Kevzara is usually given after other medications for RA have been tried and shown not to work. It is usually given in addition to other medications, such as methotrexate.


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