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How does Taltz work?

Medically reviewed by Carmen Pope, BPharm. Last updated on June 2, 2025.

Official Answer by Drugs.com

The active ingredient in Taltz, ixekizumab, is a monoclonal antibody that works by inhibiting the inflammatory response in adults with plaque psoriasis, active psoriatic arthritis, active ankylosing spondylitis, and non-radiographic axial spondyloarthritis.

Taltz selectively binds with interleukin 17A (IL-17A) cytokine, a naturally occurring substance that can cause inflammation. Taltz inhibits the release of pro-inflammatory cytokines and chemokines by inhibiting the interaction of IL-17A with the IL-17 receptor.

Taltz affects the immune system. It may increase the risk of infections, which can be serious. Taltz should not be used in patients who have any symptoms of infection, unless a doctor advises otherwise.

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What are Monoclonal Antibodies and how do they work?

Monoclonal antibodies (mAbs) are man-made proteins that mimic the natural antibodies produced by our immune systems. Monoclonal antibodies can be formulated into medicines to treat various types of illnesses, such as cancer, rheumatoid arthritis or psoriasis.

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What are IL-17 Inhibitors and how do they work?

IL-17 inhibitors are biologic drugs that block interleukin-17, a key protein that fuels inflammation in autoimmune diseases.

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What are 6 key Taltz side effects to watch out for?

Common side effects of Taltz include injection site reactions, conjunctivitis, and nausea. More serious side effects include infections, inflammatory bowel disease, and severe allergic reactions. Continue reading

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