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How does Rhofade work?

Medically reviewed by Last updated on Jan 29, 2020.

Official Answer


Rhofade is a vasocontrictor which leads to shrinkage of facial blood vessels to lessen redness.

Rhofade (oxymetazoline hydrochloride) cream 1%, from Allergan, is an alpha1A adrenoceptor agonist used on the skin (topically) to treat facial redness due to rosacea that does not go away.

Oxymetazoline is also available over-the-counter (OTC) in an eye drop solution used to reduce eye redness (brand names: Visine, Ocuclear), and as an OTC nasal spray decongestant (brand names: Afrin, Sinex, 12-Hour Nasal) used for the temporary relief of nasal congestion (stuffy nose) caused by allergies or the common cold.

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