Is Genvoya better than Stribild?
Yes, Genvoya was designed as a new and improved version of Stribild, it has a similar clinical effect on HIV but a better safety profile.
What is the difference between Genvoya and Stribild?
Genvoya and Stribild are both four-drug HIV medications, they have three ingredients the same
(cobicistat 150mg, elvitegravir 150mg, emtricitabine 200mg).
For the fourth ingredient:
- Genvoya has tenofovir alafenamide (TAF) 10mg and
- Stribild has tenofovir disoproxil fumerate (TDF) 300mg.
Stribild was the first of these two medicines to be approved by the FDA on 27 August 2012.
Genvoya was approved on 5 November 2015.
Why did they change tenofovir disoproxil fumerate (TDF) to tenofovir alafenamide (TAF) for Genvoya?
- Tenofovir disoproxil fumerate, which is one of the ingredients in Stribild, can have side effects of being toxic to the kidneys and can reduce bone density.
- To overcome this issue Genvoya was developed which replaced tenofovir disoproxil fumerate with tenofovir alafenamide which has improved safety for kidney and bones.
- Genvoya had the same clinical effect as Stribild but had better kidney and bone safety when compared to Stribild.
Bottom line:
- Genvoya was designed to have the same clinical effect against HIV as Stribild, but have improved renal and bone safety when compared to Stribild.
- Genvoya contains tenofovir alafenamide (TAF) 10mg with cobicistat 150mg, elvitegravir 150mg and emtricitabine 200mg
- Stribild contains tenofovir disoproxil fumarate (TDF) 300mg with cobicistat 150mg, elvitegravir 150mg and emtricitabine 200mg
References
- Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60616-X/fulltext
- Genvoya Medication Information: https://www.drugs.com/genvoya.html
- Stribild Medication Information: https://www.drugs.com/stribild.html
Read next
What is Genvoya used to treat?
Genvoya is an oral prescription medicine used to treat human immunodeficiency virus (HIV) in adults and children who are at least 12 years old and who weigh at least 55 pounds (25 kilograms). Continue reading
How long does Genvoya stay in your system?
Genvoya is a fixed-dose combination tablet used to treat human immunodeficiency virus (HIV) 1 infection. It contains four different drugs: cobicistat, elvitegravir, emtricitabine and tenofovir alafenamide.
To eliminate the active antiviral agents in Genvoya (elvitegravir, emtricitabine and tenofovir alafenamide) from your system takes up to 70.95 hours. Continue reading
Is Genvoya used for PrEP?
No, Genyova is not approved for pre-exposure prophylaxis (PrEP). Genvoya is used to treat (not prevent) HIV infection. It is an oral tablet taken once a day with food and is a complete HIV treatment regimen. It is not used with other HIV medicines. Continue reading
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Drug information
- Genvoya (129 reviews)
- Stribild (88 reviews)
- Cobicistat / elvitegravir / emtricitabine / tenofovir (88 reviews)
- Cobicistat / elvitegravir / emtricitabine / tenofovir Alafenamide (129 reviews)
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