What is Doptelet used for and how does it work?
How long does it take for Doptelet to work?
Doptelet (avatrombopag) is used to increase the level of platelets in the blood, in patients who have low platelet levels (thrombocytopenia) with:
- chronic liver disease (CLD) and are scheduled to undergo a procedure or
- chronic immune thrombocytopenia (ITP) and have not had a good response from another treatment.
Low platelet levels risk
- If your platelet levels are low, you are at greater risk of serious bleeding or bruising during procedures or surgery, as your blood will not clot properly.
- Symptoms of low platelet levels are bruising, blood in urine or bowel motions, fatigue, enlarged spleen and heavy menstrual flows.
- Platelets role within the blood is to help blood clot by clumping together and blocking up blood vessels when there are injuries.
How does Doptelet work?
Platelet production in the body starts with hematopoietic stem cells (HSCs), which develop into megakaryoctye cells that make platelets.
Doptelet works by increasing the number of hematopoietic stem cells, which leads to the production of more megakaryocytes and, in turn, raises platelet levels.
Doptelet mechanism of action is as a thrombopoietin receptor agonist, one of the platelet-stimulating agents.
How long does Doptelet take to work?
- Doptelet takes approximately 10 to 13 days for the platelet levels to be increased.
- For patients with chronic liver disease that are scheduled to undergo a procedure Doptelet should be started 10 to 13 days before scheduled procedure.
- The duration of the Doptelet course is 5 days and procedure should be done 5 to 8 days after the last dose of Doptelet.
Bottom line:
- Low level of platelets in the blood (thrombocytopenia) increases your risk of bleeding, bruising, blood in urine or bowel motions, fatigue, enlarged spleen, heavy menstrual flows. If you have a procedure or surgery there is a risk of severe bleeding or bruising.
- Doptelet can increase platelet levels over 10 to 13 days to reduce risk of bruising and bleeding from procedure or surgeries
References
Doptelet Medication Information: https://www.drugs.com/pro/doptelet.html
Avatrombopag for the treatment of immune thrombocytopenia and thrombocytopenia of chronic liver disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733339/
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How do you take Doptelet before a medical or dental procedure?
When used to reduce the risk of bleeding and low platelet counts in adults with chronic liver disease scheduled to undergo a medical or dental procedure, Doptelet is taken once a day for 5 days in a row, starting 10 to 13 days before the procedure. Continue reading
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How long does Nplate (romiplostim) take to work?
Nplate starts working from the first dose to increase platelet counts. The median time to first platelet response was 2.1 weeks, according the the results of a single-arm, open-label study conducted in 75 adults with immune thrombocytopenia.
Nplate should be discontinued after 4 weeks of treatment at the maximum dose of 10 mcg/kg a week if platelet counts have not increased to sufficient levels. Continue reading
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