What is Doptelet used for and how does it work?
How long does it take for Doptelet to work?
Doptelet (avatrombopag) is used to treat low platelet levels (thrombocytopenia) in:
- adults with chronic liver disease (CLD) who are scheduled to undergo a procedure (adults) or
- adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment
- children 1 year and older with persistent or chronic ITP who have had an insufficient response to a previous treatment.
Low platelet levels risk
- If your platelet levels are low, you are at greater risk of serious bleeding or bruising during procedures or surgery, as your blood will not clot properly.
- Symptoms of low platelet levels are bruising, blood in urine or bowel motions, fatigue, enlarged spleen, and heavy menstrual flow.
- Platelets' role within the blood is to help blood clot by clumping together and blocking blood vessels when there are injuries.
How does Doptelet work?
Platelet production in the body starts with hematopoietic stem cells (HSCs), which develop into megakaryocyte cells that make platelets.
Doptelet works by increasing the number of hematopoietic stem cells, which leads to the production of more megakaryocytes and, in turn, raises platelet levels.
Doptelet's mechanism of action is as a thrombopoietin receptor agonist, one of the platelet-stimulating agents.
How long does Doptelet take to work?
- Doptelet takes approximately 10 to 13 days for the platelet levels to be increased.
- For patients with chronic liver disease who are scheduled to undergo a procedure, Doptelet should be started 10 to 13 days before the scheduled procedure.
- The duration of the Doptelet course is 5 days, and the procedure should be done 5 to 8 days after the last dose of Doptelet.
Bottom line:
- Low level of platelets in the blood (thrombocytopenia) increases your risk of bleeding, bruising, blood in urine or bowel motions, fatigue, enlarged spleen, heavy menstrual flows. If you have a procedure or surgery there is a risk of severe bleeding or bruising.
- Doptelet can increase platelet levels over 10 to 13 days to reduce risk of bruising and bleeding from procedure or surgeries
References
Doptelet Prescription Information: https://www.drugs.com/pro/doptelet.html
Avatrombopag for the treatment of immune thrombocytopenia and thrombocytopenia of chronic liver disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733339/
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