Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- epinephrine ophthalmic
- Harmonyl (deserpidine)
Interactions between your drugs
deserpidine EPINEPHrine ophthalmic
Applies to: Harmonyl (deserpidine), epinephrine ophthalmic
MONITOR: Postganglionic adrenergic blocking agents may potentiate the pharmacologic effects of direct-acting sympathomimetic amines, while the hypotensive effect of the former may be diminished. Postganglionic adrenergic blocking agents such as guanadrel, guanethidine, and rauwolfia alkaloids work by depleting catecholamine stores from adrenergic nerve endings, thus they may sensitize adrenergic receptors to direct-acting sympathomimetics. Clinically, hypertension and other cardiovascular adverse effects may occur.
MANAGEMENT: Due to their pressor effect, sympathomimetic amines should be used cautiously in patients with hypertension. Conversely, alternatives to postganglionic adrenergic blocking agents should be considered in patients treated with sympathomimetic amines. If the combination is used, blood pressure and heart rate should be closely monitored.
References (3)
- Spiers AS, Calne DB (1969) "Action of dopamine on the human iris." Br Med J, 4, p. 333-5
- Muelheims GH, Entrup RW, Paiewonsky D, Mierzwiak DS (1965) "Increased sensitivity of the heart to catecholamine-induced arrhythmias following guanethidine." Clin Pharmacol Ther, 6, p. 757-62
- Limbird LE eds., Gilman AG, Hardman JG (1995) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: McGraw-Hill
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Lumigan
Lumigan is used to treat open angle glaucoma. Learn about side effects, interactions and indications.
Xalatan
Xalatan (latanoprost) is used to treat certain types of glaucoma. Includes Xalatan side effects ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Cosopt
Cosopt reduces the amount of fluid in the eye and is used to treat glaucoma. Learn about side ...
Alphagan P
Alphagan P is used to treat glaucoma or ocular hypertension (high pressure inside the eye). Learn ...
Vyzulta
Vyzulta is used for glaucoma, open angle, glaucoma/intraocular hypertension
Bimatoprost ophthalmic
Bimatoprost ophthalmic is used for glaucoma, open angle, intraocular hypertension
Dorzolamide ophthalmic
Dorzolamide ophthalmic is used for glaucoma, open angle, intraocular hypertension
Brimonidine ophthalmic
Brimonidine ophthalmic is used for eye redness, glaucoma, open angle, intraocular hypertension
Pilocarpine ophthalmic
Pilocarpine ophthalmic is used for glaucoma, glaucoma, narrow angle, glaucoma, open angle ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.